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MULTIPLE SCLEROSIS

Microglia clean up toxic lipids in multiple sclerosis

Nature Neuroscience volume 24, pages 451–452 (2021)Cite this article

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Dong and colleagues investigated mechanisms mediating neurodegeneration in multiple sclerosis and identified a direct role for oxidized phosphatidylcholines (OxPCs) in driving CNS cell death. Microglia activity, mediated by the lipid sensor TREM2 and a neutralizing OxPC antibody, were capable of rescuing OxPC-induced neurotoxicity.

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Fig. 1: Proposed model of the role of TREM2+ microglia in clearing and detoxifying oxidized phospholipids in demyelinating MS lesions.

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Authors and Affiliations

  1. Denali Therapeutics Inc., South San Francisco, CA, USA

    Kathryn M. Monroe & Gilbert Di Paolo

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  1. Kathryn M. Monroe
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  2. Gilbert Di Paolo
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Correspondence to Gilbert Di Paolo.

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The author declares no competing interests.

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Monroe, K.M., Di Paolo, G. Microglia clean up toxic lipids in multiple sclerosis. Nat Neurosci 24, 451–452 (2021). https://doi.org/10.1038/s41593-021-00829-1

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