Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jucker, M. & Walker, L. C. Nature 501, 45–51 (2013).
Jucker, M. & Walker, L. C. Nat. Neurosci. 21, 1341–1349 (2018).
Brettschneider, J., Del Tredici, K., Lee, V. M. Y. & Trojanowski, J. Q. Nat. Rev. Neurosci. 16, 109–120 (2015).
Henderson, M.X. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0457-5 (2019).
Gödert, M., Spillantini, M. G., Del Tredici, K. & Braak, H. Nat. Rev. Neuro. 9, 13–24 (2013).
Spillantini, M. G. et al. Nature 388, 839–840 (1997).
Braak, H. et al. Neurobio. Aging 24, 197–211 (2003).
Jankovic, J. et al. J. Am. Med. Assn. Neurol. 75, 1206–1214 (2018).
Weickenmeier, J., Kuhl, E. & Goriely, A. Phys. Rev. Lett. 121, 158101 (2018).
Bassett, D. S. & Bullmore, E. T. Neuroscientist 25, 499–516 (2017).
Pandja, S. et al. NeuroImage 192, 178–194 (2019).
Iturria-Medina, Y. et al. PLoS Comp. Bio. 10, e1003965 (2014).
Raj, A., Kuceyeski, A. & Weiner, M. Neuron 73, 1204–1215 (2012).
Knowles, T. P. J. et al. Science 326, 1533–1537 (2009).
Weickenmeier, J., Jucker, M., Goriely, A. & Kuhl, E. J. Mech. Phys. Solids 124, 264–281 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Kuhl, E. Connectomics of neurodegeneration. Nat Neurosci 22, 1200–1202 (2019). https://doi.org/10.1038/s41593-019-0459-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-019-0459-3