We introduce a biomimetic antigen-presenting system that uses hexapod heterostructures for specific T cell recognition at the single-molecule and single-cell levels. The system enables high-resolution T cell activation, uses magnetic forces to increase immune responses, and offers flexible and precise identification of antigen-specific T cell receptors, aiding the study of T cell recognition and immune cell mechanics.
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This is a summary of: Huang, X. et al. Multimodal probing of T-cell recognition with hexapod heterostructures. Nat. Methods https://doi.org/10.1038/s41592-023-02165-7 (2024)
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A biomimetic robotic antigen-presenting system for sensitive T cell recognition. Nat Methods (2024). https://doi.org/10.1038/s41592-023-02164-8
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DOI: https://doi.org/10.1038/s41592-023-02164-8
