A validated biomarker risk score based on the expression of 34 genes improves risk stratification of patients with meningioma, including prediction of post-operative radiotherapy benefit.
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References
Chen, W. C. et al. Radiotherapy and radiosurgery for meningiomas. Neurooncol. Adv. 5, i67–i83 (2023). A review that summarizes the literature on meningioma classification and treatment.
Choudhury, A. et al. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat. Genet. 54, 649–659 (2022). A study of meningioma molecular groups using DNA-methylation profiling.
Choudhury, A. et al. Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Neuro Oncol. 25, 520–530 (2023). A study of meningioma molecular subgroups using DNA-methylation profiling.
Patel, A. J. et al. Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors. Proc. Natl Acad. Sci. USA 116, 21715–21726 (2019). A study of meningioma molecular groups using RNA sequencing.
Nassiri, F. et al. A clinically applicable integrative molecular classification of meningiomas. Nature 597, 119–125 (2021). A paper reporting a meningioma molecular classification using DNA-methylation profiling, RNA sequencing, copy-number variants and somatic short variants.
Louis, D. et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 23, 1231–1251 (2021). A paper summarizing the 2021 World Health Organization classification of central nervous system tumors.
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This is a summary of: Chen, W. C. et al. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat. Med. https://doi.org/10.1038/s41591-023-02586-z (2023).
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Meningioma risk stratification with a targeted gene-expression biomarker. Nat Med 29, 3020–3021 (2023). https://doi.org/10.1038/s41591-023-02642-8
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DOI: https://doi.org/10.1038/s41591-023-02642-8
