Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

AUTOIMMUNITY

Mitochondrial dysfunction in the erythroid compartment

The retention of erythroid mitochondria, a feature associated with impairments in the ubiquitin–proteasome system, is detected in a subset of pediatric patients with lupus and is associated with the type I interferon pathway.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Deficient mitochondrial removal and association with type I IFN responses.

References

  1. Casey, K. A. et al. Arthritis Rheumatol. 73, 459–471 (2021).

    Article  CAS  Google Scholar 

  2. Kim, J. et al. Science 366, 1531–1536 (2019).

    Article  CAS  Google Scholar 

  3. Rai, P. et al. Nat. Immunol. 22, 312–321 (2021).

    Article  CAS  Google Scholar 

  4. Lood, C. et al. Nat. Med. 22, 146–153 (2016).

    Article  CAS  Google Scholar 

  5. Caza, T. N. et al. Ann. Rheum. Dis. 73, 1888–1897 (2014).

    Article  CAS  Google Scholar 

  6. Melki, I. et al. Sci. Transl. Med. 13, eaav5928 (2021).

    Article  CAS  Google Scholar 

  7. Caielli, S. et al. Cell 184, 4464–4479 (2021).

    Article  CAS  Google Scholar 

  8. Kapitsinou, P. P. et al. Blood 116, 3039–3048 (2010).

    Article  CAS  Google Scholar 

  9. Torrelo, A. Front. Immunol. 8, 927 (2017).

    Article  Google Scholar 

  10. Tumburu, L. et al. Blood 137, 3116–3126 (2021).

    Article  CAS  Google Scholar 

  11. Palanichamy, A. et al. J. Immunol. 192, 906–918 (2014).

    Article  CAS  Google Scholar 

  12. Wolf-Levy, H. et al. Nat. Biotechnol. 36, 1110–1116 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mariana J. Kaplan.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kaplan, M.J. Mitochondrial dysfunction in the erythroid compartment. Nat Immunol 22, 1354–1355 (2021). https://doi.org/10.1038/s41590-021-01050-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-021-01050-9

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research