SWAP-70 and DEF6 prevent the cytokine IL-21–induced transcription factor IRF5 from binding to DNA and recruiting the transcription factor T-bet and thereby diminish the activation of age-associated B cells.
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Zou, YR., Davidson, A. Age-associated B cells acquire a new wrinkle. Nat Immunol 19, 317–318 (2018). https://doi.org/10.1038/s41590-018-0072-8
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DOI: https://doi.org/10.1038/s41590-018-0072-8