Controlled positioning of the mitotic spindle is key to tissue development and homeostasis. A recent study uncovered an EB1 crotonylation event that orchestrates microtubule dynamics in late mitosis, thus ensuring correct division orientation in vertebrate cells.
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References
Santaguida, S. & Amon, A. Nat. Rev. Mol. Cell Biol. 16, 473–485 (2015).
Cuijpers, S. A. G. & Vertegaal, A. C. O. Trends Biochem. Sci. 43, 251–268 (2018).
Song, X. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00875-7 (2021).
Lechler, T. & Mapelli, M. Nat. Rev. Mol. Cell. Biol. https://doi.org/10.1038/s41580-021-00384-4 (2021).
Akhmanova, A. & Steinmetz, M. O. Nat. Rev. Mol. Cell Biol. 9, 309–322 (2008).
Nehlig, A., Molina, A., Rodrigues-Ferreira, S., Honore, S. & Nahmias, C. Cell. Mol. Life Sci. 74, 2381–2393 (2017).
Zhang, R., LaFrance, B. & Nogales, E. Proc. Natl Acad. Sci. USA 115, E6191–E6200 (2018).
Tan, M. et al. Cell 146, 1016–1028 (2011).
Kotak, S., Busso, C. & Gonczy, P. J. Cell Biol. 199, 97–110 (2012).
Janke, C. & Magiera, M. M. Nat. Rev. Mol. Cell Biol. 21, 307–326 (2020).
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Santaguida, S., Mapelli, M. Crotonylation directs the spindle. Nat Chem Biol 17, 1217–1218 (2021). https://doi.org/10.1038/s41589-021-00881-9
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DOI: https://doi.org/10.1038/s41589-021-00881-9
