Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer dependencies

Hyperactivation of oncogenic driver pathways as a precision therapeutic strategy

Nature Genetics volume 55, pages 1613–1614 (2023)Cite this article

Subjects

Many precision cancer therapies function by inhibiting oncogenic signaling pathways. A new study describes the counterintuitive finding that forced hyperactivation of the same pathways can also enable selective tumor targeting.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic depicting the relationship between oncogenic pathway activity and cellular fitness.

References

  1. Chang, L. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01515-7 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Chang, L., Ruiz, P., Ito, T. & Sellers, W. R. Cancer Cell 39, 466–479 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Konieczkowski, D. J., Johannessen, C. M. & Garraway, L. A. Cancer Cell 33, 801–815 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Courtois-Cox, S., Jones, S. L. & Cichowski, K. Oncogene 27, 2801–2809 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Das Thakur, M. et al. Nature 494, 251–255 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ito, T. et al. Nat. Genet. 53, 1664–1672 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Seong, B. K. A. et al. Cancer Cell 39, 1262–1278.e7 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ahn, E. H. Anticancer Res. 33, 2029–2035 (2013).

    CAS  PubMed  Google Scholar 

  9. The Cancer Genome Atlas. Nature 487, 330–337 (2012).

    Article  Google Scholar 

  10. Christie, M. et al. Oncogene 32, 4675–4682 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Ranes, M., Zaleska, M., Sakalas, S., Knight, R. & Guettler, S. Mol. Cell. 81, 3246–3261.e11 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Schneikert, J., Grohmann, A. & Behrens, J. Hum. Mol. Genet. 16, 199–209 (2007).

    Article  CAS  PubMed  Google Scholar 

  13. Kong, X. et al. Nature 550, 270–274 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hong, A. et al. Cancer Discov. 8, 74–93 (2018).

    Article  CAS  PubMed  Google Scholar 

  15. Anforth, R., Fernandez-Penas, P. & Long, G. V. Lancet Oncol. 14, e11 (2013).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA

    Kris C. Wood

Authors
  1. Kris C. Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kris C. Wood.

Ethics declarations

Competing interests

The author declares no competing financial interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wood, K.C. Hyperactivation of oncogenic driver pathways as a precision therapeutic strategy. Nat Genet 55, 1613–1614 (2023). https://doi.org/10.1038/s41588-023-01493-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-023-01493-w

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer