In this issue, Deng and colleagues show that the RNA m6A modification reader FXR1 recruits DNA 5-methylcytosine dioxygenase TET1 to genomic regions in order to demethylate DNA, which highlights a crosstalk between RNA methylation and DNA methylation in chromatin.
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Xu, W., Shen, H. When RNA methylation meets DNA methylation. Nat Genet 54, 1261–1262 (2022). https://doi.org/10.1038/s41588-022-01166-0
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DOI: https://doi.org/10.1038/s41588-022-01166-0
