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Imaging glycosylated RNAs at the subcellular scale

Nature Biotechnology volume 42, pages 574–575 (2024)Cite this article

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A recently discovered RNA species on the cell surface is studied by proximity ligation.

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Fig. 1: Neu5Ac-binding aptamer meets an RNA sequence-specific binding probe to detect sialoglycoRNA in situ.

References

  1. Abels, E. R. & Breakefield, X. O. Cell. Mol. Neurobiol. 36, 301–312 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ma, Y. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01801-z (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Flynn, R. A. et al. Cell 184, 3109–3124.e22 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Weiss, L. & Mayhew, E. J. Cell. Physiol. 68, 345–359 (1966).

    Article  CAS  Google Scholar 

  5. Huang, N. et al. Genome Biol. 21, 225 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Scache, J. et al. Sci. Rep. 12, 22129 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hemberger, H. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.02.26.530106 (2023).

  8. Fredriksson, S. et al. Nat. Biotechnol. 20, 473–477 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. Cheng, B., Tang, Q., Zhang, C. & Chen, X. Annu. Rev. Anal. Chem. (Palo Alto, Calif.) 14, 363–387 (2021).

    Article  CAS  PubMed  Google Scholar 

  10. Dobie, C. & Skropeta, D. Br. J. Cancer 124, 76–90 (2021).

    Article  CAS  PubMed  Google Scholar 

  11. Varki, N. M. & Varki, A. Lab. Invest. 87, 851–857 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ahlin, E. et al. Lupus 21, 586–595 (2012).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA

    Petar Hristov

  2. Stem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA, USA

    Petar Hristov & Ryan A. Flynn

  3. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA

    Ryan A. Flynn

  4. Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

    Ryan A. Flynn

Authors
  1. Petar Hristov
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  2. Ryan A. Flynn
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Correspondence to Ryan A. Flynn.

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The authors declare no competing interests.

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Hristov, P., Flynn, R.A. Imaging glycosylated RNAs at the subcellular scale. Nat Biotechnol 42, 574–575 (2024). https://doi.org/10.1038/s41587-023-02021-1

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