Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Genomics

A genome-wide view of disordered proteins

Transcription factors containing disordered regions can now be mapped across the genome, aiding functional studies.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: DisP-seq identifies genomic regions that contain proteins with intrinsically disordered regions.

References

  1. Xing, Y.-H. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01737-4 (2023).

    Article  PubMed  Google Scholar 

  2. van der Lee, R. et al. Chem. Rev. 114, 6589–6631 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Morgunova, E. & Taipale, J. Curr. Opin. Struct. Biol. 47, 1–8 (2017).

    Article  CAS  PubMed  Google Scholar 

  4. Brodsky, S., Jana, T. & Barkai, N. Curr. Opin. Struct. Biol. 71, 110–115 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Han, T. W. et al. Cell 149, 768–779 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Riggi, N. et al. Cancer Cell 26, 668–681 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ravarani, C. N. et al. Mol. Syst. Biol. 14, e8190 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Benz, C. et al. Mol. Syst. Biol. 18, e10584 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ahn, J. H. et al. Nature 595, 591–595 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chandra, B. et al. Cancer Discov. 12, 1152–1169 (2022).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Benjamin J. Leslie, Benjamin Lang or M. Madan Babu.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Leslie, B.J., Lang, B. & Babu, M.M. A genome-wide view of disordered proteins. Nat Biotechnol 42, 32–34 (2024). https://doi.org/10.1038/s41587-023-01955-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-023-01955-w

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research