Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

Karczewski, Konrad J.; Francioli, Laurent C.; Tiao, Grace; Cummings, Beryl B.; Alföldi, Jessica; Wang, Qingbo; Collins, Ryan L.; Laricchia, Kristen M.; Ganna, Andrea; Birnbaum, Daniel P.; Gauthier, Laura D.; Brand, Harrison; Solomonson, Matthew; Watts, Nicholas A.; Rhodes, Daniel; Singer-Berk, Moriel; England, Eleina M.; Seaby, Eleanor G.; Kosmicki, Jack A.; Walters, Raymond K.; Tashman, Katherine; Farjoun, Yossi; Banks, Eric; Poterba, Timothy; Wang, Arcturus; Seed, Cotton; Whiffin, Nicola; Chong, Jessica X.; Samocha, Kaitlin E.; Pierce-Hoffman, Emma; Zappala, Zachary; O’Donnell-Luria, Anne H.; Minikel, Eric Vallabh; Weisburd, Ben; Lek, Monkol; Ware, James S.; Vittal, Christopher; Armean, Irina M.; Bergelson, Louis; Cibulskis, Kristian; Connolly, Kristen M.; Covarrubias, Miguel; Donnelly, Stacey; Ferriera, Steven; Gabriel, Stacey; Gentry, Jeff; Gupta, Namrata; Jeandet, Thibault; Kaplan, Diane; Llanwarne, Christopher; Munshi, Ruchi; Novod, Sam; Petrillo, Nikelle; Roazen, David; Ruano-Rubio, Valentin; Saltzman, Andrea; Schleicher, Molly; Soto, Jose; Tibbetts, Kathleen; Tolonen, Charlotte; Wade, Gordon; Talkowski, Michael E.; Neale, Benjamin M.; Daly, Mark J.; MacArthur, Daniel G.

doi:10.1038/s41586-020-03174-8

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Author Correction
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Published: 03 February 2021

Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski ORCID: orcid.org/0000-0003-2878-4671^1,2,
Laurent C. Francioli ORCID: orcid.org/0000-0002-3039-8895^1,2,
Grace Tiao^1,2,
Beryl B. Cummings^1,2,3,
Jessica Alföldi ORCID: orcid.org/0000-0001-9713-6200^1,2,
Qingbo Wang ORCID: orcid.org/0000-0002-9110-5830^1,2,4,
Ryan L. Collins ORCID: orcid.org/0000-0003-1268-9995^1,4,5,
Kristen M. Laricchia^1,2,
Andrea Ganna^1,2,6,
Daniel P. Birnbaum^1,2,
Laura D. Gauthier⁷,
Harrison Brand^1,5,
Matthew Solomonson^1,2,
Nicholas A. Watts^1,2,
Daniel Rhodes⁸,
Moriel Singer-Berk^1,2,
Eleina M. England^1,2,
Eleanor G. Seaby^1,2,
Jack A. Kosmicki^1,2,4,
Raymond K. Walters ORCID: orcid.org/0000-0001-8422-6530^1,2,9,
Katherine Tashman^1,2,9,
Yossi Farjoun ORCID: orcid.org/0000-0002-7002-2868⁷,
Eric Banks⁷,
Timothy Poterba^1,2,9,
Arcturus Wang^1,2,9,
Cotton Seed^1,2,9,
Nicola Whiffin^1,2,10,11,
Jessica X. Chong¹²,
Kaitlin E. Samocha ORCID: orcid.org/0000-0002-1704-3352¹³,
Emma Pierce-Hoffman^1,2,
Zachary Zappala^1,2,14,
Anne H. O’Donnell-Luria ORCID: orcid.org/0000-0001-6418-9592^1,2,15,16,
Eric Vallabh Minikel¹,
Ben Weisburd⁷,
Monkol Lek¹⁷,
James S. Ware ORCID: orcid.org/0000-0002-6110-5880^1,10,11,
Christopher Vittal^2,9,
Irina M. Armean ORCID: orcid.org/0000-0002-1043-4756^1,2,
Louis Bergelson⁷,
Kristian Cibulskis⁷,
Kristen M. Connolly¹⁸,
Miguel Covarrubias⁷,
Stacey Donnelly¹,
Steven Ferriera¹⁸,
Stacey Gabriel¹⁸,
Jeff Gentry⁷,
Namrata Gupta^1,18,
Thibault Jeandet⁷,
Diane Kaplan⁷,
Christopher Llanwarne⁷,
Ruchi Munshi⁷,
Sam Novod⁷,
Nikelle Petrillo⁷,
David Roazen⁷,
Valentin Ruano-Rubio⁷,
Andrea Saltzman¹,
Molly Schleicher¹,
Jose Soto⁷,
Kathleen Tibbetts⁷,
Charlotte Tolonen⁷,
Gordon Wade⁷,
Michael E. Talkowski ORCID: orcid.org/0000-0003-2889-0992^1,5,19,
Genome Aggregation Database Consortium,
Benjamin M. Neale ORCID: orcid.org/0000-0003-1513-6077^1,2,9,
Mark J. Daly^1,2,6,9 &
…
Daniel G. MacArthur ORCID: orcid.org/0000-0002-5771-2290^1,2^nAff150^nAff151

Nature volume 590, page E53 (2021)Cite this article

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The Original Article was published on 27 May 2020

Correction to: Nature https://doi.org/10.1038/s41586-020-2308-7 Published online 27 May 2020

In this Article, author Marquis P. Vawter was missing from the Genome Aggregation Database Consortium list. They are associated with the affiliation: ‘Department of Psychiatry & Human Behavior, University of California Irvine, Irvine, CA, USA’, and contributed to the generation of the primary data incorporated into the gnomAD resource. In addition, in the legend to Fig. 1, ‘ten’ should have been ‘seven’ in the sentence: “a, Uniform manifold approximation and projection (UMAP)^46,47 plot depicting the ancestral diversity of all individuals in gnomAD, using seven principal components.” The original Article has been corrected online.

Author information

Daniel G. MacArthur
Present address: Centre for Population Genomics, Garvan Institute of Medical Research, and UNSW Sydney, Sydney, New South Wales, Australia
Daniel G. MacArthur
Present address: Centre for Population Genomics, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
Deceased: Pamela Sklar

Authors and Affiliations

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo Wang, Ryan L. Collins, Kristen M. Laricchia, Andrea Ganna, Daniel P. Birnbaum, Harrison Brand, Matthew Solomonson, Nicholas A. Watts, Moriel Singer-Berk, Eleina M. England, Eleanor G. Seaby, Jack A. Kosmicki, Raymond K. Walters, Katherine Tashman, Timothy Poterba, Arcturus Wang, Cotton Seed, Nicola Whiffin, Emma Pierce-Hoffman, Zachary Zappala, Anne H. O’Donnell-Luria, Eric Vallabh Minikel, James S. Ware, Irina M. Armean, Stacey Donnelly, Namrata Gupta, Andrea Saltzman, Molly Schleicher, Michael E. Talkowski, Mark J. Daly, Patrick T. Ellinor, Tõnu Esko, Jose Florez, Steven A. Lubitz, Daniel G. MacArthur, James B. Meigs, Benjamin M. Neale, Aarno Palotie, Samuli Ripatti, Jeremiah Scharf, James S. Ware, Benjamin M. Neale, Mark J. Daly & Daniel G. MacArthur
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo Wang, Kristen M. Laricchia, Andrea Ganna, Daniel P. Birnbaum, Matthew Solomonson, Nicholas A. Watts, Moriel Singer-Berk, Eleina M. England, Eleanor G. Seaby, Jack A. Kosmicki, Raymond K. Walters, Katherine Tashman, Timothy Poterba, Arcturus Wang, Cotton Seed, Nicola Whiffin, Emma Pierce-Hoffman, Zachary Zappala, Anne H. O’Donnell-Luria, Christopher Vittal, Irina M. Armean, Mark J. Daly, Daniel G. MacArthur, Benjamin M. Neale, Benjamin M. Neale, Mark J. Daly & Daniel G. MacArthur
Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA
Beryl B. Cummings
Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA
Qingbo Wang, Ryan L. Collins & Jack A. Kosmicki
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Ryan L. Collins, Harrison Brand, Michael E. Talkowski, Sekar Kathiresan & Jeremiah Scharf
Institute for Molecular Medicine Finland, Helsinki, Finland
Andrea Ganna, Leif Groop, Jaakko Kaprio, Aarno Palotie, Samuli Ripatti, Tuomi Tiinamaija, Maija Wessman & Mark J. Daly
Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Laura D. Gauthier, Yossi Farjoun, Eric Banks, Ben Weisburd, Louis Bergelson, Kristian Cibulskis, Miguel Covarrubias, Jeff Gentry, Thibault Jeandet, Diane Kaplan, Christopher Llanwarne, Ruchi Munshi, Sam Novod, Nikelle Petrillo, David Roazen, Valentin Ruano-Rubio, Jose Soto, Kathleen Tibbetts, Charlotte Tolonen, Gordon Wade & Jose Florez
Centre for Translational Bioinformatics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK
Daniel Rhodes
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Raymond K. Walters, Katherine Tashman, Timothy Poterba, Arcturus Wang, Cotton Seed, Christopher Vittal, Mark J. Daly, Steven McCarroll, Aarno Palotie, Jeremiah Scharf, Benjamin M. Neale & Mark J. Daly
National Heart & Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK
Nicola Whiffin, James S. Ware, Jaspal Kooner & James S. Ware
Cardiovascular Research Centre, Royal Brompton & Harefield Hospitals NHS Trust, London, UK
Nicola Whiffin, James S. Ware & James S. Ware
Department of Pediatrics, University of Washington, Seattle, WA, USA
Jessica X. Chong
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Kaitlin E. Samocha
Vertex Pharmaceuticals Inc, Boston, MA, USA
Zachary Zappala
Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA
Anne H. O’Donnell-Luria
Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Anne H. O’Donnell-Luria
Department of Genetics, Yale School of Medicine, New Haven, CT, USA
Monkol Lek
Broad Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Kristen M. Connolly, Steven Ferriera, Stacey Gabriel & Namrata Gupta
Department of Neurology, Harvard Medical School, Boston, MA, USA
Michael E. Talkowski
Unidad de Investigacion de Enfermedades Metabolicas, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
Carlos A. Aguilar Salinas
Peninsula College of Medicine and Dentistry, Exeter, UK
Tariq Ahmad
Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Christine M. Albert & Daniel Chasman
Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Christine M. Albert
Department of Cardiology, University Hospital, Parma, Italy
Diego Ardissino
Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
Gil Atzmon
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
Gil Atzmon
Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
Gil Atzmon
Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
John Barnard & Mina K. Chung
Sorbonne Université, APHP, Gastroenterology Department, Saint Antoine Hospital, Paris, France
Laurent Beaugerie & Harry Sokol
Framingham Heart Study, National Heart, Lung, & Blood Institute and Boston University, Framingham, MA, USA
Emelia J. Benjamin & Josée Dupuis
Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Emelia J. Benjamin
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
Emelia J. Benjamin
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
Michael Boehnke
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Lori L. Bonnycastle
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Erwin P. Bottinger, Judy Cho & Ruth J. F. Loos
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA
Donald W. Bowden
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA
Donald W. Bowden
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA
Donald W. Bowden
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Matthew J. Bown & Nilesh J. Samani
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK
Matthew J. Bown & Nilesh J. Samani
Department of Epidemiology and Biostatistics, Imperial College London, London, UK
John C. Chambers & Jaspal Kooner
Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
John C. Chambers & Jaspal Kooner
Imperial College Healthcare NHS Trust, Imperial College London, London, UK
John C. Chambers & Jaspal Kooner
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Juliana C. Chan & Ronald C. W. Ma
Department of Medicine, Harvard Medical School, Boston, MA, USA
Daniel Chasman, Bruce Cohen, Gad Getz, Sekar Kathiresan, James B. Meigs & Dost Ongur
Program for Neuropsychiatric Research, McLean Hospital, Belmont, MA, USA
Bruce Cohen & Dost Ongur
Department of Medicine, University of Mississippi Medical Center, Jackson, MI, USA
Adolfo Correa
Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA
Dana Dabelea
Department of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
Dawood Darbar
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
Ravindranath Duggirala
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Josée Dupuis
Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Patrick T. Ellinor & Steven A. Lubitz
Cardiovascular Epidemiology and Genetics, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain
Roberto Elosua
Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (CIBERCV), Barcelona, Catalonia, Spain
Roberto Elosua & Jaume Marrugat
Department of Medicine, Medical School, University of Vic-Central University of Catalonia, Vic, Catalonia, Spain
Roberto Elosua
Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany
Jeanette Erdmann
DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany
Jeanette Erdmann
University Heart Center Lübeck, Lübeck, Germany
Jeanette Erdmann
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Tõnu Esko & Andres Metspalu
Helsinki University and Helsinki University Hospital, Clinic of Gastroenterology, Helsinki, Finland
Martti Färkkilä
Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA
Jose Florez
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Jose Florez & Pamela Sklar
Program in Metabolism, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Jose Florez
Institute of Clinical Molecular Biology (IKMB), Christian-Albrechts-University of Kiel, Kiel, Germany
Andre Franke
Bioinformatics Consortium, Massachusetts General Hospital, Boston, MA, USA
Gad Getz
Cancer Genome Computational Analysis, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Gad Getz
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Gad Getz
Cancer Center, Massachusetts General Hospital, Boston, MA, USA
Gad Getz
Endocrinology and Metabolism Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Benjamin Glaser
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA
Stephen J. Glatt
Institute for Genomic Medicine, Columbia University Medical Center, Hammer Health Sciences, New York, NY, USA
David Goldstein
Department of Genetics and Development, Columbia University Medical Center, Hammer Health Sciences, New York, NY, USA
David Goldstein
Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Mexico
Clicerio Gonzalez
Genomics, Diabetes and Endocrinology, Lund University, Lund, Sweden
Leif Groop
Lund University Diabetes Centre, Malmö, Sweden
Christopher Haiman
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
Craig Hanis
Department of Neurology, Columbia University, New York, NY, USA
Matthew Harms
Institute of Genomic Medicine, Columbia University, New York, NY, USA
Matthew Harms
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
Mikko Hiltunen
Department of Psychiatry, Helsinki University Central Hospital, Lapinlahdentie, Helsinki, Finland
Matti M. Holi
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Christina M. Hultman & Patrick F. Sullivan
Icahn School of Medicine at Mount Sinai, New York, NY, USA
Christina M. Hultman
Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
Mikko Kallela
Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Jaakko Kaprio, Samuli Ripatti & Erkki Vartiainen
Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Sekar Kathiresan
Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, South Korea
Bong-Jo Kim & Young Jin Kim
MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University School of Medicine, Cardiff, UK
George Kirov, Michael C. O’Donovan & Michael J. Owen
Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland
Seppo Koskinen
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
Harlan M. Krumholz
Division of Pediatric Gastroenterology, Emory University School of Medicine, Atlanta, GA, USA
Subra Kugathasan
Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Soo Heon Kwak & Kyong Soo Park
Institute of Clinical Medicine, The University of Eastern Finland, Kuopio, Finland
Markku Laakso
Kuopio University Hospital, Kuopio, Finland
Markku Laakso
Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Terho Lehtimäki & Kari M. Mattila
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Ruth J. F. Loos
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Ronald C. W. Ma
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China
Ronald C. W. Ma
Cardiovascular Research REGICOR Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain
Jaume Marrugat
Department of Genetics, Harvard Medical School, Boston, MA, USA
Steven McCarroll
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK
Mark I. McCarthy
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
Mark I. McCarthy
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK
Mark I. McCarthy
F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Dermot McGovern
Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Canada
Ruth McPherson
Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA
James B. Meigs
Department of Clinical Sciences, University Hospital Malmo Clinical Research Center, Lund University, Malmo, Sweden
Olle Melander
Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden
Peter M. Nilsson
Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico
Lorena Orozco
Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Colin N. A. Palmer
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea
Kyong Soo Park
Department of Psychiatry, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
Carlos Pato
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann E. Pulver
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK
Nazneen Rahman
Medical Research Center, Oulu University Hospital, Oulu, Finland and Research Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland
Anne M. Remes
Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
John D. Rioux
Department of Medicine, Faculty of Medicine, Université de Montréal, Quebec, Canada
John D. Rioux
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
Dan M. Roden
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Dan M. Roden
Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Danish Saleheen
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Danish Saleheen
Center for Non-Communicable Diseases, Karachi, Pakistan
Danish Saleheen
National Institute for Health and Welfare, Helsinki, Finland
Veikko Salomaa & Jaana Suvisaari
Deutsches Herzzentrum München, Munich, Germany
Heribert Schunkert
Technische Universität München, Munich, Germany
Heribert Schunkert
Division of Cardiovascular Medicine, Nashville VA Medical Center and Vanderbilt University, School of Medicine, Nashville, TN, USA
Moore B. Shoemaker
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Pamela Sklar
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Pamela Sklar
Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Pamela Sklar
Institute of Clinical Medicine, Neurology, University of Eastern Finlad, Kuopio, Finland
Hilkka Soininen
Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
Tim Spector
Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA
Patrick F. Sullivan
Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore
E. Shyong Tai & Yik Ying Teo
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
E. Shyong Tai
Duke-NUS Graduate Medical School, Singapore, Singapore
E. Shyong Tai
Life Sciences Institute, National University of Singapore, Singapore, Singapore
Yik Ying Teo
Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore
Yik Ying Teo
Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland
Tuomi Tiinamaija & Maija Wessman
HUCH Abdominal Center, Helsinki University Hospital, Helsinki, Finland
Tuomi Tiinamaija
Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, CA, USA
Ming Tsuang
Institute of Genomic Medicine, University of California, San Diego, CA, USA
Ming Tsuang
Juliet Keidan Instit.ute of Pediatric Gastroenterology, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
Dan Turner
Instituto de Investigaciones Biomédicas UNAM, Mexico City, Mexico
Teresa Tusie-Luna
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Teresa Tusie-Luna
Department of Psychiatry & Human Behavior, University of California Irvine, Irvine, CA, USA
Marquis P. Vawter
Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Hugh Watkins
Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
Rinse K. Weersma
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
James G. Wilson
Program in Infectious Disease and Microbiome, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Ramnik J. Xavier
Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA
Ramnik J. Xavier

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Konrad J. Karczewski
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Laurent C. Francioli
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Grace Tiao
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Beryl B. Cummings
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Jessica Alföldi
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Qingbo Wang
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Ryan L. Collins
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Kristen M. Laricchia
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Andrea Ganna
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Daniel P. Birnbaum
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Harrison Brand
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Matthew Solomonson
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Nicholas A. Watts
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Daniel Rhodes
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Moriel Singer-Berk
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Eleina M. England
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Eleanor G. Seaby
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Jack A. Kosmicki
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Raymond K. Walters
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Katherine Tashman
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Eric Banks
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Timothy Poterba
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Arcturus Wang
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Cotton Seed
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Anne H. O’Donnell-Luria
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Eric Vallabh Minikel
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Monkol Lek
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James S. Ware
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Christopher Vittal
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Irina M. Armean
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Louis Bergelson
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Kristian Cibulskis
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Kristen M. Connolly
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Miguel Covarrubias
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Stacey Donnelly
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Steven Ferriera
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Correspondence to Konrad J. Karczewski or Daniel G. MacArthur.

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Karczewski, K.J., Francioli, L.C., Tiao, G. et al. Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans. Nature 590, E53 (2021). https://doi.org/10.1038/s41586-020-03174-8

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Published: 03 February 2021
Issue Date: 18 February 2021
DOI: https://doi.org/10.1038/s41586-020-03174-8

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Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

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Polygenic risk alters the penetrance of monogenic kidney disease

Two sporadic cases of childhood-onset Hailey-Hailey disease with superimposed mosaicism

Patterns and distribution of de novo mutations in multiplex Middle Eastern families

Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia

Novel genes bearing mutations in rare cases of early-onset ataxia with cerebellar hypoplasia

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Polygenic risk alters the penetrance of monogenic kidney disease

Two sporadic cases of childhood-onset Hailey-Hailey disease with superimposed mosaicism

Patterns and distribution of de novo mutations in multiplex Middle Eastern families

Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia

Novel genes bearing mutations in rare cases of early-onset ataxia with cerebellar hypoplasia

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