A post hoc analysis of the COAPT trial suggests that transcatheter mitral valve repair for secondary mitral regurgitation is efficacious in patients with heart failure and chronic kidney disease. The intervention also reduced the risk of kidney failure, raising hypotheses regarding the mechanisms that link heart failure and loss of kidney function.
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References
Beohar, N. et al. Impact of baseline renal dysfunction on cardiac outcomes and end-stage renal disease in heart failure patients with mitral regurgitation: the COAPT trial. Eur. Heart J. ehac026 (2022).
Stone, G. W. et al. Transcatheter mitral-valve repair in patients with heart failure. N. Engl. J. Med. 379, 2307–2318 (2018).
Obadia, J.-F. et al. Percutaneous repair or medical treatment for secondary mitral regurgitation. N. Engl. J. Med. 379, 2297–2306 (2018).
Sawalha, K. et al. Impact of chronic kidney disease on in-hospital outcomes and readmission rate after edge-to-edge transcatheter mitral valve repair. Catheter. Cardiovasc. Interv. 97, E569–E579 (2021).
Dave, P. et al. The effect of transcatheter mitral valve repair on short-term mortality in patients with chronic kidney disease — a systematic review and meta-analysis. Cardiovasc. Revasc. Med. 30, 78–84 (2021).
Konstantinidis, I. et al. Representation of patients with kidney disease in trials of cardiovascular interventions: an updated systematic review. JAMA Intern. Med. 176, 121–124 (2016).
Kaneko, H., Neuss, M., Schau, T., Weissenborn, J. & Butter, C. Interaction between renal function and percutaneous edge-to-edge mitral valve repair using MitraClip. J. Cardiol. 69, 476–482 (2017).
Kubo, S. et al. Impact of forward stroke volume response on clinical and structural outcomes after percutaneous mitral valve repair with MitraClip. Circ. Cardiovasc. Interv. 10, e004909 (2017).
Wang, A. et al. Evaluation of renal function before and after percutaneous mitral valve repair. Circ. Cardiovasc. Interv. 8, e001349 (2015).
Rassaf, T. et al. Influence of percutaneous mitral valve repair using the MitraClip® system on renal function in patients with severe mitral regurgitation. Catheter. Cardiovasc. Interv. 85, 899–903 (2015).
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W.M. receives funding support from KL2 TR002545-04.
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McCallum, W., Sarnak, M.J. Transcatheter mitral valve repair in patients with CKD. Nat Rev Nephrol 18, 483–484 (2022). https://doi.org/10.1038/s41581-022-00583-y
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DOI: https://doi.org/10.1038/s41581-022-00583-y
