Abstract
Microscale robots have been the focus of extensive research efforts resulting in various innovative developments that broaden their capabilities and applications. The rational design of materials has been the cornerstone for developing and innovating microscale robots, and breakthroughs in materials science are expected to further push the boundaries of this field. This Review provides an overview of the design principles and material selection for the propulsion and operation of microrobots. The fundamental mechanisms governing the motion of microrobots are first introduced, followed by the material design strategies enabling efficient and controllable propulsion. We highlight the use of diverse reactive and responsive materials in realizing the advanced functionalities and capabilities of microrobots, cover representative biomedical and environmental applications and discuss how future material innovations will impact the development of next-generation microscale robots.
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References
Wang, J. Will future microbots be task-specific customized machines or multi-purpose ‘all in one’ vehicles? Nat. Commun. 12, 7125 (2021).
Urso, M., Ussia, M. & Pumera, M. Smart micro- and nanorobots for water purification. Nat. Rev. Bioeng. 1, 236–251 (2023).
Li, J., Esteban-Fernández de Ávila, B., Gao, W., Zhang, L. & Wang, J. Micro/nanorobots for biomedicine: delivery, surgery, sensing, and detoxification. Sci. Robot. 2, eaam6431 (2017).
Yoo, J., Tang, S. & Gao, W. Micro- and nanorobots for biomedical applications in the brain. Nat. Rev. Bioeng. 1, 308–310 (2023).
Guix, M., Mayorga-Martinez, C. C. & Merkoçi, A. Nano/micromotors in (bio)chemical science applications. Chem. Rev. 114, 6285–6322 (2014).
Karshalev, E., Esteban-Fernández de Ávila, B. & Wang, J. Micromotors for ‘chemistry-on-the-fly’. J. Am. Chem. Soc. 140, 3810–3820 (2018).
Soto, F. et al. Smart materials for microrobots. Chem. Rev. 122, 5365–5403 (2022).
Wang, H. & Pumera, M. Emerging materials for the fabrication of micro/nanomotors. Nanoscale 9, 2109–2116 (2017).
Purcell, E. M. Life at low Reynolds number. Am. J. Phys. 45, 3–11 (1977).
Wang, J. Nanomachines: Fundamentals and Applications (Wiley, 2013).
Kumar, M. S. & Philominathan, P. The physics of flagellar motion of E. coli during chemotaxis. Biophys. Rev. 2, 13–20 (2010).
Wang, J., Xiong, Z., Zheng, J., Zhan, X. & Tang, J. Light-driven micro/nanomotor for promising biomedical tools: principle, challenge, and prospect. Acc. Chem. Res. 51, 1957–1965 (2018).
Zhou, Y. et al. Stimuli-responsive functional micro-/nanorobots: a review. ACS Nano 17, 15254–15276 (2023).
Šípová-Jungová, H., Andrén, D., Jones, S. & Käll, M. Nanoscale inorganic motors driven by light: principles, realizations, and opportunities. Chem. Rev. 120, 269–287 (2020).
Liu, T. et al. Controlled propulsion of micro/nanomotors: operational mechanisms, motion manipulation and potential biomedical applications. Chem. Soc. Rev. 51, 10083–10119 (2022).
Peng, F., Tu, Y. & Wilson, D. A. Micro/nanomotors towards in vivo application: cell, tissue and biofluid. Chem. Soc. Rev. 46, 5289–5310 (2017).
Zhang, B., Zhu, L., Pan, H. & Cai, L. Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery. Expert Opin. Drug Deliv. 20, 1427–1441 (2023).
Dong, Y. et al. Magnetic helical micro-/nanomachines: recent progress and perspective. Matter 5, 77–109 (2022).
Chen, G. et al. Towards the next generation nanorobots. Nanotechnology 2, 100019 (2023).
Sánchez, S., Soler, L. & Katuri, J. Chemically powered micro- and nanomotors. Angew. Chem. Int. Ed. 54, 1414–1444 (2015).
Mathesh, M., Sun, J. & Wilson, D. A. Enzyme catalysis powered micro/nanomotors for biomedical applications. J. Mater. Chem. B 8, 7319–7334 (2020).
Paxton, W. F. et al. Catalytic nanomotors: autonomous movement of striped nanorods. J. Am. Chem. Soc. 126, 13424–13431 (2004).
Paxton, W. F. et al. Catalytically induced electrokinetics for motors and micropumps. J. Am. Chem. Soc. 128, 14881–14888 (2006).
Fournier-Bidoz, S., Arsenault, A. C., Manners, I. & Ozin, G. A. Synthetic self-propelled nanorotors. Chem. Commun. 41, 441–443 (2005).
Kuron, M., Kreissl, P. & Holm, C. Toward understanding of self-electrophoretic propulsion under realistic conditions: from bulk reactions to confinement effects. Acc. Chem. Res. 51, 2998–3005 (2018).
Demirok, U. K., Laocharoensuk, R., Manesh, K. M. & Wang, J. Ultrafast catalytic alloy nanomotors. Angew. Chem. Int. Ed. 47, 9349–9351 (2008).
Laocharoensuk, R., Burdick, J. & Wang, J. Carbon-nanotube-induced acceleration of catalytic nanomotors. ACS Nano 2, 1069–1075 (2008).
Pourrahimi, A. M. & Pumera, M. Multifunctional and self-propelled spherical Janus nano/micromotors: recent advances. Nanoscale 10, 16398–16415 (2018).
Howse, J. R. et al. Self-motile colloidal particles: from directed propulsion to random walk. Phys. Rev. Lett. 99, 048102 (2007).
Valadares, L. F. et al. Catalytic nanomotors: self-propelled sphere dimers. Small 6, 565–572 (2010).
Ebel, J., Anderson, J. L. & Prieve, D. Diffusiophoresis of latex particles in electrolyte gradients. Langmuir 4, 396–406 (1988).
Wang, W., Duan, W., Ahmed, S., Mallouk, T. E. & Sen, A. Small power: autonomous nano- and micromotors propelled by self-generated gradients. Nano Today 8, 531–554 (2013).
Ibele, M., Mallouk, T. E. & Sen, A. Schooling behavior of light‐powered autonomous micromotors in water. Angew. Chem. Int. Ed. 121, 3358–3362 (2009).
Hong, Y., Diaz, M., Córdova-Figueroa, U. M. & Sen, A. Light-driven titanium-dioxide-based reversible microfireworks and micromotor/micropump systems. Adv. Funct. Mater. 20, 1568–1576 (2010).
Moran, J. L. & Posner, J. D. Phoretic self-propulsion. Annu. Rev. Fluid Mech. 49, 511–540 (2017).
Gao, W., Sattayasamitsathit, S., Orozco, J. & Wang, J. Highly efficient catalytic microengines: template electrosynthesis of polyaniline/platinum microtubes. J. Am. Chem. Soc. 133, 11862–11864 (2011).
Li, J. et al. Dry-released nanotubes and nanoengines by particle-assisted rolling. Adv. Mater. 25, 3715–3721 (2013).
Gao, W. et al. Seawater-driven magnesium based Janus micromotors for environmental remediation. Nanoscale 5, 4696–4700 (2013).
Mou, F. et al. Self-propelled micromotors driven by the magnesium–water reaction and their hemolytic properties. Angew. Chem. Int. Ed. 52, 7208–7212 (2013).
Li, J. et al. Enteric micromotor can selectively position and spontaneously propel in the gastrointestinal tract. ACS Nano 10, 9536–9542 (2016).
Gao, W. et al. Artificial micromotors in the mouse’s stomach: a step toward in vivo use of synthetic motors. ACS Nano 9, 117–123 (2015).
Hortelao, A. C. et al. Swarming behavior and in vivo monitoring of enzymatic nanomotors within the bladder. Sci. Robot. 6, eabd2823 (2021).
Hortelão, A. C., Carrascosa, R., Murillo-Cremaes, N., Patiño, T. & Sánchez, S. Targeting 3D bladder cancer spheroids with urease-powered nanomotors. ACS Nano 13, 429–439 (2019).
Zhou, H., Mayorga-Martinez, C. C., Pané, S., Zhang, L. & Pumera, M. Magnetically driven micro and nanorobots. Chem. Rev. 121, 4999–5041 (2021).
Peyer, K. E., Tottori, S., Qiu, F., Zhang, L. & Nelson, B. J. Magnetic helical micromachines. Chem. Eur. J. 19, 28–38 (2013).
Tottori, S. et al. Magnetic helical micromachines: fabrication, controlled swimming, and cargo transport. Adv. Mater. 24, 811–816 (2012).
Dong, Y. et al. Endoscope-assisted magnetic helical micromachine delivery for biofilm eradication in tympanostomy tube. Sci. Adv. 8, eabq8573 (2022).
Gao, W. et al. Bioinspired helical microswimmers based on vascular plants. Nano Lett. 14, 305–310 (2014).
Schwarz, L. et al. A rotating spiral micromotor for noninvasive zygote transfer. Adv. Sci. 7, 2000843 (2020).
You, M., Mou, F., Wang, K. & Guan, J. Tadpole-like flexible microswimmers with the head and tail both magnetic. ACS Appl. Mater. Interfaces 15, 40855–40863 (2023).
Baraban, L. et al. Fuel-free locomotion of Janus motors: magnetically induced thermophoresis. ACS Nano 7, 1360–1367 (2013).
Xu, T. et al. Dynamic morphology and swimming properties of rotating miniature swimmers with soft tails. IEEE ASME Trans. Mechatron. 24, 924–934 (2019).
Villa, K. Exploring innovative designs and heterojunctions in photocatalytic micromotors. Chem. Commun. 59, 8375–8383 (2023).
Maric, T., Nasir, M. Z. M., Webster, R. D. & Pumera, M. Tailoring metal/TiO2 interface to influence motion of light-activated Janus micromotors. Adv. Funct. Mater. 30, 1908614 (2020).
Ibele, M., Mallouk, T. E. & Sen, A. Schooling behavior of light-powered autonomous micromotors in water. Angew. Chem. Int. Ed. 48, 3308–3312 (2009).
Dong, R., Zhang, Q., Gao, W., Pei, A. & Ren, B. Highly efficient light-driven TiO2-Au Janus micromotors. ACS Nano 10, 839–844 (2016).
Villa, K. et al. Visible-light-driven single-component BiVO4 micromotors with the autonomous ability for capturing microorganisms. ACS Nano 13, 8135–8145 (2019).
Chen, C. et al. Light-steered isotropic semiconductor micromotors. Adv. Mater. 29, 1603374 (2017).
Jang, B. et al. Multiwavelength light-responsive Au/B-TiO2 Janus micromotors. ACS Nano 11, 6146–6154 (2017).
Dai, B. et al. Programmable artificial phototactic microswimmer. Nat. Nanotechnol. 11, 1087–1092 (2016).
Tong, J. et al. Bioinspired micro/nanomotor with visible light energy-dependent forward, reverse, reciprocating, and spinning schooling motion. Proc. Natl Acad. Sci. USA 118, e2104481118 (2021).
Wang, H. et al. Light-driven biomimetic nanomotors for enhanced photothermal therapy. Small 20, 2306208 (2024).
Shao, J., Cao, S., Williams, D. S., Abdelmohsen, L. K. E. A. & van Hest, J. C. M. Photoactivated polymersome nanomotors: traversing biological barriers. Angew. Chem. Int. Ed. 59, 16918–16925 (2020).
Zhang, Y. et al. Highly penetrable drug-loaded nanomotors for photothermal-enhanced ferroptosis treatment of tumor. ACS Appl. Mater. Interfaces 15, 14099–14110 (2023).
Wang, W., Castro, L. A., Hoyos, M. & Mallouk, T. E. Autonomous motion of metallic microrods propelled by ultrasound. ACS Nano 6, 6122–6132 (2012).
Ahmed, S. et al. Density and shape effects in the acoustic propulsion of bimetallic nanorod motors. ACS Nano 10, 4763–4769 (2016).
Loget, G. & Kuhn, A. Electric field-induced chemical locomotion of conducting objects. Nat. Commun. 2, 535 (2011).
Diwakar, N. M., Kunti, G., Miloh, T., Yossifon, G. & Velev, O. D. AC electrohydrodynamic propulsion and rotation of active particles of engineered shape and asymmetry. Curr. Opin. Colloid Interface Sci. 59, 101586 (2022).
Li, H. et al. Precise electrokinetic position and three-dimensional orientation control of a nanowire bioprobe in solution. Nat. Nanotechnol. 18, 1213–1221 (2023).
Gangwal, S., Cayre, O. J., Bazant, M. Z. & Velev, O. D. Induced-charge electrophoresis of metallodielectric particles. Phys. Rev. Lett. 100, 058302 (2008).
Calvo-Marzal, P. et al. Propulsion of nanowire diodes. Chem. Commun. 46, 1623–1624 (2010).
Chang, S. T., Paunov, V. N., Petsev, D. N. & Velev, O. D. Remotely powered self-propelling particles and micropumps based on miniature diodes. Nat. Mater. 6, 235–240 (2007).
Chen, C., Soto, F., Karshalev, E., Li, J. & Wang, J. Hybrid nanovehicles: one machine, two engines. Adv. Funct. Mater. 29, 1806290 (2019).
Gao, W., Manesh, K. M., Hua, J., Sattayasamitsathit, S. & Wang, J. Hybrid nanomotor: a catalytically/magnetically powered adaptive nanowire swimmer. Small 7, 2047–2051 (2011).
Palagi, S. & Fischer, P. Bioinspired microrobots. Nat. Rev. Mater. 3, 113–124 (2018).
Felfoul, O. et al. Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nat. Nanotechnol. 11, 941–947 (2016).
Zhang, F. et al. Biohybrid microalgae robots: design, fabrication, materials and applications. Adv. Mater. 36, 2303714 (2024).
Ricotti, L. et al. Biohybrid actuators for robotics: a review of devices actuated by living cells. Sci. Robot. 2, eaaq0495 (2017).
Magdanz, V., Sanchez, S. & Schmidt, O. G. Development of a sperm-flagella driven micro-bio-robot. Adv. Mater. 25, 6581–6588 (2013).
Weibel, D. B. et al. Microoxen: microorganisms to move microscale loads. Proc. Natl Acad. Sci. USA 102, 11963–11967 (2005).
Yu, S., Cai, Y., Wu, Z. & He, Q. Recent progress on motion control of swimming micro/nanorobots. VIEW 2, 20200113 (2021).
Fusi, A. D. et al. Achieving control in micro/nanomotor mobility. Angew. Chem. Int. Ed. 135, e202214754 (2023).
Wang, J. & Manesh, K. M. Motion control at the nanoscale. Small 6, 338–345 (2010).
Teo, W. Z. & Pumera, M. Motion control of micro-/nanomotors. Chem. Eur. J. 22, 14796–14804 (2016).
Kline, T. R., Paxton, W. F., Mallouk, T. E. & Sen, A. Catalytic nanomotors: remote-controlled autonomous movement of striped metallic nanorods. Angew. Chem. Int. Ed. 44, 744–746 (2005).
Karshalev, E. et al. Utilizing iron’s attractive chemical and magnetic properties in microrocket design, extended motion, and unique performance. Small 13, 1700035 (2017).
Balasubramanian, S. et al. Thermal modulation of nanomotor movement. Small 5, 1569–1574 (2009).
Ma, X., Wang, X., Hahn, K. & Sánchez, S. Motion control of urea-powered biocompatible hollow microcapsules. ACS Nano 10, 3597–3605 (2016).
Xu, T. et al. Ultrasound-modulated bubble propulsion of chemically powered microengines. J. Am. Chem. Soc. 136, 8552–8555 (2014).
Palagi, S., Singh, D. P. & Fischer, P. Light-controlled micromotors and soft microrobots. Adv. Opt. Mater. 7, 1900370 (2019).
Chen, C. et al. Chemical/light-powered hybrid micromotors with ‘on-the-fly’ optical brakes. Angew. Chem. Int. Ed. 57, 8110–8114 (2018).
Guo, J., Gallegos, J. J., Tom, A. R. & Fan, D. Electric-field-guided precision manipulation of catalytic nanomotors for cargo delivery and powering nanoelectromechanical devices. ACS Nano 12, 1179–1187 (2018).
Magdanz, V., Stoychev, G., Ionov, L., Sanchez, S. & Schmidt, O. G. Stimuli-responsive microjets with reconfigurable shape. Angew. Chem. Int. Ed. 53, 2673–2677 (2014).
Chen, C. et al. Bioinspired chemical communication between synthetic nanomotors. Angew. Chem. Int. Ed. 57, 241–245 (2018).
Wu, Z. et al. Cell-membrane-coated synthetic nanomotors for effective biodetoxification. Adv. Funct. Mater. 25, 3881–3887 (2015).
Tang, S. et al. Enzyme-powered Janus platelet cell robots for active and targeted drug delivery. Sci. Robot. 5, eaba6137 (2020).
Zhang, H. et al. Dual-responsive biohybrid neutrobots for active target delivery. Sci. Robot. 6, eaaz9519 (2021).
Go, G. et al. Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo. Sci. Robot. 5, eaay6626 (2020).
Zhang, F. et al. Biomembrane-functionalized micromotors: biocompatible active devices for diverse biomedical applications. Adv. Mater. 34, 2107177 (2022).
Chen, C. et al. Transient micromotors that disappear when no longer needed. ACS Nano 10, 10389–10396 (2016).
Solovev, A. A., Sanchez, S. & Schmidt, O. G. Collective behaviour of self-propelled catalytic micromotors. Nanoscale 5, 1284–1293 (2013).
Liu, J. et al. Swarming multifunctional heater–thermometer nanorobots for precise feedback hyperthermia delivery. ACS Nano 17, 16731–16742 (2023).
Law, J. et al. Microrobotic swarms for selective embolization. Sci. Adv. 8, eabm5752 (2022).
Wang, B. et al. Spatiotemporally actuated hydrogel by magnetic swarm nanorobotics. ACS Nano 16, 20985–21001 (2022).
Ceron, S., Gardi, G., Petersen, K. & Sitti, M. Programmable self-organization of heterogeneous microrobot collectives. Proc. Natl Acad. Sci. USA 120, e2221913120 (2023).
Del Campo Fonseca, A. et al. Ultrasound trapping and navigation of microrobots in the mouse brain vasculature. Nat. Commun. 14, 5889 (2023).
Wang, X. et al. Colloidal tubular microrobots for cargo transport and compression. Proc. Natl Acad. Sci. USA 120, e2304685120 (2023).
Jin, D., Yu, J., Yuan, K. & Zhang, L. Mimicking the structure and function of ant bridges in a reconfigurable microswarm for electronic applications. ACS Nano 13, 5999–6007 (2019).
Ahmed, S., Gentekos, D. T., Fink, C. A. & Mallouk, T. E. Self-assembly of nanorod motors into geometrically regular multimers and their propulsion by ultrasound. ACS Nano 8, 11053–11060 (2014).
Ahmed, D. et al. Neutrophil-inspired propulsion in a combined acoustic and magnetic field. Nat. Commun. 8, 770 (2017).
Yang, H., Wang, L. & Huang, X. MOF-based micro/nanomotors (MOFtors): recent progress and challenges. Coord. Chem. Rev. 495, 215372 (2023).
Feng, J. et al. Covalent organic framework-based nanomotor for multimodal cancer photo-theranostics. Adv. Healthc. Mater. 495, e202301645 (2023).
Peng, X. et al. Autonomous metal–organic framework nanorobots for active mitochondria-targeted cancer therapy. Sci. Adv. 9, eadh1736 (2023).
Sridhar, V. et al. Designing covalent organic framework-based light-driven microswimmers toward therapeutic applications. Adv. Mater. 35, 2301126 (2023).
Wang, H. & Pumera, M. Fabrication of micro/nanoscale motors. Chem. Rev. 115, 8704–8735 (2015).
Wang, J. Template electrodeposition of catalytic nanomotors. Faraday Discuss. 164, 9–18 (2013).
Manesh, K. M. et al. Template-assisted fabrication of salt-independent catalytic tubular microengines. ACS Nano 4, 1799–1804 (2010).
Gao, W. et al. Polymer-based tubular microbots: role of composition and preparation. Nanoscale 4, 2447–2453 (2012).
Mei, Y. et al. Versatile approach for integrative and functionalized tubes by strain engineering of nanomembranes on polymers. Adv. Mater. 20, 4085–4090 (2008).
Baraban, L. et al. Catalytic Janus motors on microfluidic chip: deterministic motion for targeted cargo delivery. ACS Nano 6, 3383–3389 (2012).
Schamel, D. et al. Chiral colloidal molecules and observation of the propeller effect. J. Am. Chem. Soc. 135, 12353–12359 (2013).
Gibbs, J. & Zhao, Y. P. Design and characterization of rotational multicomponent catalytic nanomotors. Small 5, 2304–2308 (2009).
Li, J. & Pumera, M. 3D printing of functional microrobots. Chem. Soc. Rev. 50, 2794–2838 (2021).
Dabbagh, S. R. et al. 3D-printed microrobots from design to translation. Nat. Commun. 13, 5875 (2022).
Ceylan, H. et al. 3D-printed biodegradable microswimmer for theranostic cargo delivery and release. ACS Nano 13, 3353–3362 (2019).
Wu, Z. et al. Near-infrared light-triggered ‘on/off’ motion of polymer multilayer rockets. ACS Nano 8, 6097–6105 (2014).
Xie, L. et al. Kinetics-controlled super-assembly of asymmetric porous and hollow carbon nanoparticles as light-sensitive smart nanovehicles. J. Am. Chem. Soc. 144, 1634–1646 (2022).
Alapan, Y. et al. Soft erythrocyte-based bacterial microswimmers for cargo delivery. Sci. Robot. 3, eaar4423 (2018).
Bao, T. et al. Drug-loaded zwitterion-based nanomotors for the treatment of spinal cord injury. ACS Appl. Mater. Interfaces 15, 32762–32771 (2023).
Chen, H. et al. A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma. Nat. Commun. 14, 941 (2023).
Yang, Q. et al. Pollen typhae-based magnetic-powered microrobots toward acute gastric bleeding treatment. ACS Appl. Bio Mater. 5, 4425–4434 (2022).
Esteban-Fernández de Ávila, B. et al. Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nat. Commun. 8, 272 (2017).
Zhang, F. et al. Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia. Nat. Mater. 21, 1324–1332 (2022).
Choi, H., Cho, S. H. & Hahn, S. K. Urease-powered polydopamine nanomotors for intravesical therapy of bladder diseases. ACS Nano 14, 6683–6692 (2020).
Wei, X. et al. Biomimetic micromotor enables active delivery of antigens for oral vaccination. Nano Lett. 19, 1914–1921 (2019).
Nelson, B. J., Kaliakatsos, I. K. & Abbott, J. J. Microrobots for minimally invasive medicine. Annu. Rev. Biomed. Eng. 12, 55–85 (2010).
Pokki, J. et al. Protective coatings for intraocular wirelessly controlled microrobots for implantation: corrosion, cell culture, and in vivo animal tests. J. Biomed. Mater. Res. B 105, 836–845 (2017).
Wu, Z. et al. A swarm of slippery micropropellers penetrates the vitreous body of the eye. Sci. Adv. 4, eaat4388 (2018).
Wang, J. Self-propelled affinity biosensors: moving the receptor around the sample. Biosens. Bioelectron. 76, 234–242 (2016).
Pacheco, M., López, M. Á., Jurado-Sánchez, B. & Escarpa, A. Self-propelled micromachines for analytical sensing: a critical review. Anal. Bioanal. Chem. 411, 6561–6573 (2019).
Balasubramanian, S. et al. Micromachine-enabled capture and isolation of cancer cells in complex media. Angew. Chem. Int. Ed. 50, 4161–4164 (2011).
Venugopalan, P. L., Esteban-Fernández de Ávila, B., Pal, M., Ghosh, A. & Wang, J. Fantastic voyage of nanomotors into the cell. ACS Nano 14, 9423–9439 (2020).
Esteban-Fernández de Ávila, B. et al. Acoustically propelled nanomotors for intracellular siRNA delivery. ACS Nano 10, 4997–5005 (2016).
Uygun, D. A., Jurado-Sánchez, B., Uygun, M. & Wang, J. Self-propelled chelation platforms for efficient removal of toxic metals. Environ. Sci. Nano 3, 559–566 (2016).
Orozco, J. et al. Micromotor-based high-yielding fast oxidative detoxification of chemical threats. Angew. Chem. Int. Ed. 52, 13276–13279 (2013).
Orozco, J. et al. Bubble-propelled micromotors for enhanced transport of passive tracers. Langmuir 30, 5082–5087 (2014).
Singh, V. V. & Wang, J. Nano/micromotors for security/defense applications: a review. Nanoscale 7, 19377–19389 (2015).
Parmar, J., Vilela, D., Villa, K., Wang, J. & Sánchez, S. Micro- and nanomotors as active environmental microcleaners and sensors. J. Am. Chem. Soc. 140, 9317–9331 (2018).
Jurado-Sánchez, B. & Wang, J. Micromotors for environmental applications: a review. Environ. Sci. Nano 5, 1530–1544 (2018).
Wang, H., Khezri, B. & Pumera, M. Catalytic DNA-functionalized self-propelled micromachines for environmental remediation. Chem 1, 473–481 (2016).
Soler, L., Magdanz, V., Fomin, V. M., Sanchez, S. & Schmidt, O. G. Self-propelled micromotors for cleaning polluted water. ACS Nano 7, 9611–9620 (2013).
Li, J. et al. Water-driven micromotors for rapid photocatalytic degradation of biological and chemical warfare agents. ACS Nano 8, 11118–11125 (2014).
Guix, M. et al. Superhydrophobic alkanethiol-coated microsubmarines for effective removal of oil. ACS Nano 6, 4445–4451 (2012).
Li, J. et al. Swimming microrobot optical nanoscopy. Nano Lett. 16, 6604–6609 (2016).
Li, J. et al. Self-propelled nanomotors autonomously seek and repair cracks. Nano Lett. 15, 7077–7085 (2015).
Wang, W., Chiang, T.-Y., Velegol, D. & Mallouk, T. E. Understanding the efficiency of autonomous nano- and microscale motors. J. Am. Chem. Soc. 135, 10557–10565 (2013).
Purcell, E. M. The efficiency of propulsion by a rotating flagellum. Proc. Natl Acad. Sci. USA 94, 11307–11311 (1997).
Chattopadhyay, S., Moldovan, R., Yeung, C. & Wu, X. L. Swimming efficiency of bacterium Escherichia coli. Proc. Natl Acad. Sci. USA 103, 13712–13717 (2006).
Iwatani, S., Iwane, A. H., Higuchi, H., Ishii, Y. & Yanagida, T. Mechanical and chemical properties of cysteine-modified kinesin molecules. Biochemistry 38, 10318–10323 (1999).
Huang, W., Manjare, M. & Zhao, Y. Catalytic nanoshell micromotors. J. Phys. Chem. C 117, 21590–21596 (2013).
Manjare, M., Yang, B. & Zhao, Y. P. Bubble driven quasioscillatory translational motion of catalytic micromotors. Phys. Rev. Lett. 109, 128305 (2012).
Cichos, F., Landin, S. M. & Pradip, R. in Intelligent Nanotechnology Ch. 5 (eds Zheng, Y. & Wu, Z.) 113–144 (Elsevier, 2023).
Mou, T. et al. Bridging the complexity gap in computational heterogeneous catalysis with machine learning. Nat. Catal. 6, 122–136 (2023).
Esterhuizen, J. A., Goldsmith, B. R. & Linic, S. Interpretable machine learning for knowledge generation in heterogeneous catalysis. Nat. Catal. 5, 175–184 (2022).
Mai, H., Le, T. C., Chen, D., Winkler, D. A. & Caruso, R. A. Machine learning for electrocatalyst and photocatalyst design and discovery. Chem. Rev. 122, 13478–13515 (2022).
Wang, Y. et al. Bipolar electrochemical mechanism for the propulsion of catalytic nanomotors in hydrogen peroxide solutions. Langmuir 22, 10451–10456 (2006).
Gao, W., Pei, A., Dong, R. & Wang, J. Catalytic iridium-based Janus micromotors powered by ultralow levels of chemical fuels. J. Am. Chem. Soc. 136, 2276–2279 (2014).
Li, T. et al. Magnetically propelled fish-like nanoswimmers. Small 12, 6098–6105 (2016).
Ghosh, A. & Fischer, P. Controlled propulsion of artificial magnetic nanostructured propellers. Nano Lett. 9, 2243–2245 (2009).
Acknowledgements
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Glossary
- Bubble propulsion
-
Movement generated by the recoil force from bubbles released from the surface of micromotors.
- Janus structure
-
An asymmetric structure with two distinct domains with different chemical or physical properties.
- Micromotor
-
A microscale device capable of converting energy into movement and forces.
- Microrobots
-
A microscale device that performs a task. It consists of a micromotor and additional functions, according to the task performed.
- Microrockets
-
Self-propelled microscale open tubular micromotors.
- Motion control
-
Control of the speed and directionality of the microrobot.
- Phoretic self-propulsion
-
Movement of microrobots in response to self-built gradients, including diffusiophoresis and self-electrophoresis.
- Propulsion force
-
A force causing movement.
- Reynolds number
-
The ratio of inertial forces to viscous forces.
- Taxis
-
Movement towards or away from the source of a stimulus.
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Chen, C., Ding, S. & Wang, J. Materials consideration for the design, fabrication and operation of microscale robots. Nat Rev Mater 9, 159–172 (2024). https://doi.org/10.1038/s41578-023-00641-2
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DOI: https://doi.org/10.1038/s41578-023-00641-2