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Cancer risk after bariatric surgery — is colorectal cancer a special case?

Nature Reviews Gastroenterology & Hepatology volume 15, pages 653–654 (2018)Cite this article

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Bariatric surgery-induced weight loss is associated with reduced overall cancer incidence; however, some data suggest that risk of colorectal cancer (CRC) actually increases. Here, we suggest a need to fully characterise CRC (and colorectal adenoma) risk after bariatric surgery given that preventive measures (early diagnosis and polypectomy) can mitigate risk.

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Fig. 1: Possible intestinal pro-carcinogenic factors after Roux-en-Y gastric bypass.

References

  1. Lauby-Secretan, B. et al. Body fatness and cancer — viewpoint of the IARC Working Group. N. Engl. J. Med. 375, 794–798 (2016).

    Article  Google Scholar 

  2. Zhou, X. et al. Effects of bariatric surgery on mortality, cardiovascular events, and cancer outcomes in obese patients: systematic review and meta-analysis. Obes. Surg. 26, 2590–2601 (2016).

    Article  Google Scholar 

  3. Derogar, M. et al. Increased risk of colorectal cancer after obesity surgery. Ann. Surg. 258, 983–988 (2013).

    Article  Google Scholar 

  4. Afshar, S. et al. The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis. Obes. Surg. 24, 1793–1799 (2014).

    Article  Google Scholar 

  5. Aravani, A. et al. Obesity surgery and risk of colorectal and other obesity-related cancers: an English population-based cohort study. Cancer Epidemiol. 53, 99–104 (2018).

    Article  Google Scholar 

  6. Mackenzie, H. et al. Obesity surgery and risk of cancer. Br. J. Surg. https://doi.org/10.1002/bjs.10914 (2018).

    Article  PubMed  Google Scholar 

  7. Schauer, D. P. et al. Bariatric surgery and the risk of cancer in a large multisite cohort. Ann. Surg. https://doi.org/10.1097/SLA.0000000000002525 (2017).

    Article  PubMed  Google Scholar 

  8. Kant, P. et al. Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass. Obesity 22, 202–210 (2014).

    Article  CAS  Google Scholar 

  9. Aron-Wisnewsky, J. et al. Major microbiota dysbiosis in severe obesity: fate after bariatric surgery. Gut https://doi.org/10.1136/gutjnl-2018-316103 (2018).

    Article  PubMed  Google Scholar 

  10. Kedrin, D. et al. Bariatric surgery pirot to index screening colonoscopy is associated with a decreased rate of colorectal adenomas in obese individuals. Clin. Transl Gastroenterol. 8, e73 (2017).

    Article  Google Scholar 

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Authors and Affiliations

  1. Leeds Institute of Medical Research, University of Leeds, Leeds, UK

    Mark A. Hull & Eva J. A. Morris

  2. Department of Surgery and Cancer, Imperial College London, London, UK

    Sheraz R. Markar

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  1. Mark A. Hull
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  2. Sheraz R. Markar
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  3. Eva J. A. Morris
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Correspondence to Mark A. Hull.

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Hull, M.A., Markar, S.R. & Morris, E.J.A. Cancer risk after bariatric surgery — is colorectal cancer a special case?. Nat Rev Gastroenterol Hepatol 15, 653–654 (2018). https://doi.org/10.1038/s41575-018-0070-1

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