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De novo genes

Toxin rescue by a random sequence

A random sequence variant in an experimental screen can rescue Escherichi coli from the deleterious effects of a RNase toxin by interacting with chaperones.

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Fig. 1: The mechanism of E. coli toxin rescue by a random protein.

References

  1. Blevins, W. R. et al. Nat. Commun. 12, 604 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wacholder, A. et al. Cell Syst. 14, 363–381.e8 (2023).

    Article  CAS  PubMed  Google Scholar 

  3. Landry, C. R., Zhong, X., Nielly-Thibault, L. & Roucou, X. Curr. Opin. Struct. Biol. 32, 74–80 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Weisman, C. M. J. Mol. Evol. 90, 244–257 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Frumkin, I. & Laub, M. T. Nat. Ecol. Evol., https://doi.org/10.1038/s41559-023-02224-4 (2023).

  6. Knopp, M. et al. MBio 10, https://doi.org/10.1128/mBio.00837-19 (2019).

  7. Knopp, M. et al. PLoS Genet. 17, e1009227 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hoegler, K. J. & Hecht, M. H. Protein Sci. 25, 1249–1259 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Babina, A. M. et al. eLife 12, e78299 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bornberg-Bauer, E., Hlouchova, K. & Lange, A. Curr. Opin. Struct. Biol. 68, 175–183 (2021).

    Article  CAS  PubMed  Google Scholar 

  11. Keeling, D. M., Garza, P., Nartey, C. M. & Carvunis, A. R. eLife 8, e47014 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Vakirlis, N. et al. Nat. Commun. 11, 781 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bhave, D. & Tautz, D. Genes 13, 53 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Heames, B. et al. Nat. Ecol. Evol. 7, 570–580 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Peng, J. & Zhao, L. Preprint at bioRxiv, https://doi.org/10.1101/2023.03.13.532420 (2023).

  16. Wilson, B. A., Foy, S. G., Neme, R. & Masel, J. Nat. Ecol. Evol. 1, 0146 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  17. Tretyachenko, V. et al. Sci. Rep. 7, 15449 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  18. Aubel, M., Eicholt, L. & Bornberg-Bauer, E. F1000 Res. 12, 347 (2023).

    Article  CAS  Google Scholar 

  19. Liu, J. et al. Proteins 91, 1097–1115 (2022).

    Article  Google Scholar 

  20. Middendorf, L. & Eicholt, L. A. Preprint at bioRxiv, https://doi.org/10.1101/2023.07.18.549582 (2023).

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Correspondence to Klara Hlouchova.

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Hlouchova, K. Toxin rescue by a random sequence. Nat Ecol Evol 7, 1963–1964 (2023). https://doi.org/10.1038/s41559-023-02252-0

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