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NATURAL PRODUCTS

A radical approach to diverse meroterpenoids

Meroterpenoids are mixed terpenoid–polyketide natural products with a variety of biological activities. Now, a synthetic approach that combines biocatalytic oxidation with a range of other radical-based reactions enables the divergent synthesis of eight oxidized meroterpenoid natural products and one analogue.

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Fig. 1: Divergent synthesis of eight meroterpenoids and one analogue.

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Correspondence to Adam Nelson.

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Twitter: @Adam_S_Nelson

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Gomm, A., Nelson, A. A radical approach to diverse meroterpenoids. Nat. Chem. 12, 109–111 (2020). https://doi.org/10.1038/s41557-019-0414-7

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