Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Autophagy

ER remodelling by ER-phagy in neurogenesis

Nature Cell Biology volume 26, pages 316–317 (2024)Cite this article

Subjects

The endoplasmic reticulum (ER) controls the synthesis of lipids and proteins and Ca2+ homeostasis, as well as contacting other organelles and the plasma membrane. A study now looks at a process by which this compartment is remodelled in axons during neurogenesis: the lysosomal clearance of ER subdomains, driven by FAM134 and CCPG1 proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: ER-phagy in the neuronal axon.

References

  1. Klionsky, D. J., Eskelinen, E. L. & Deretic, V. Autophagy 10, 549–551 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Reggiori, F. & Molinari, M. Physiol. Rev. 102, 1393–1448 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gubas, A. & Dikic, I. Mol. Cell 82, 1492–1500 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kucinska, M. K. & Molinari, M. Autophagy 20, 1–3 (2024).

    Article  Google Scholar 

  5. Rudinskiy, M. & Molinari, M. FEBS Lett. 597, 1928–1945 (2023).

    Article  CAS  PubMed  Google Scholar 

  6. Hoyer, M. J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01356-4 (2024).

    Article  PubMed  Google Scholar 

  7. Ordureau, A. et al. Mol. Cell 81, 5082–5098 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yperman, K. & Kuijpers, M. Mol. Cell. Neurosci. 125, 103822 (2023).

    Article  CAS  PubMed  Google Scholar 

  9. Vats, S. & Galli, T. Autophagy 17, 1037–1039 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Hubner, C. A. & Dikic, I. Cell Death Differ. 27, 833–842 (2020).

    Article  PubMed  Google Scholar 

  11. Smith, M. D. et al. Dev. Cell 44, 217–232 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kroemer, G., Marino, G. & Levine, B. Mol. Cell 40, 280–293 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland

    Maurizio Molinari

  2. School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Maurizio Molinari

Authors
  1. Maurizio Molinari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maurizio Molinari.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Molinari, M. ER remodelling by ER-phagy in neurogenesis. Nat Cell Biol 26, 316–317 (2024). https://doi.org/10.1038/s41556-024-01362-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-024-01362-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing