The generation of clathrin-coated vesicles during endocytosis requires the co-ordinated recruitment of dozens of proteins to the plasma membrane. We discovered that the plant TPLATE (or TSET) complex (TPC) undergoes biomolecular condensation through interactions with plasma membrane phospholipids and, via weak multivalent interactions, recruits clathrin and other endocytic proteins to facilitate the efficient progression of endocytosis.
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References
Kaksonen, M. & Roux, A. Mechanisms of clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 19, 313–326 (2018). A review article that presents an overview of endocytosis.
Gadeyne, A. et al. The TPLATE adaptor complex drives clathrin-mediated endocytosis in plants. Cell. 156, 691–704 (2014). This paper reports the discovery of the endocytic TPC.
Zhang, Y. et al. Change your Tplate, change your fate: Plant CME and beyond. Trends Plant Sci. 20, 41–48 (2015). A review article that summarizes the function and evolution of the TPC.
Day, K. J. et al. Liquid-like protein interactions catalyse assembly of endocytic vesicles. Nat. Cell Biol. 23, 366–376 (2021). This paper reports the discovery that the human EPS15 and FCHO proteins form condensates, which initiate endocytosis.
Kozak, M. & Kaksonen, M. Condensation of Ede1 promotes the initiation of endocytosis. eLife 11, e72865 (2022). This paper reports the discovery that the yeast Ede1 protein forms condensates, which initiate endocytosis.
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This is a summary of: Dragwidge, J. M. et al. Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01354-6 (2024).
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Order and disorder in clathrin-mediated endocytosis. Nat Cell Biol 26, 327–328 (2024). https://doi.org/10.1038/s41556-024-01355-5
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DOI: https://doi.org/10.1038/s41556-024-01355-5
