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Cancer

Targeting stromal metabolism in pancreatic ductal adenocarcinoma

Nature Cell Biology volume 26, pages 514–515 (2024)Cite this article

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The tumour microenvironment produces nutrients that propel cancer development. New work finds that pancreatic ductal adenocarcinoma cells use one such nutrient, acetate, to alter protein acetylation, rerouting polyamine metabolism and promoting cell growth under acidosis—a finding with potential implications for treating this cancer.

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Fig. 1: CAFs potentiate the growth of PDAC cells through acetate-mediated metabolic rewiring under acidosis.

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Authors and Affiliations

  1. Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, Cancer Institutes, School of Basic Medical Sciences, Key Laboratory of Breast Cancer in Shanghai, Shanghai Key Laboratory of Radiation Oncology, The Shanghai Key Laboratory of Medical Epigenetics, The State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China

    Miao Yin & Qun-Ying Lei

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Miao Yin & Qun-Ying Lei

  3. New Cornerstone Science Laboratory, Shanghai, China

    Qun-Ying Lei

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  1. Miao Yin
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  2. Qun-Ying Lei
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Correspondence to Miao Yin or Qun-Ying Lei.

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The authors declare no competing interests.

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Yin, M., Lei, QY. Targeting stromal metabolism in pancreatic ductal adenocarcinoma. Nat Cell Biol 26, 514–515 (2024). https://doi.org/10.1038/s41556-023-01330-6

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