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Neurodegeneration

Autophagy prevents microglial senescence

Nature Cell Biology volume 25, pages 923–925 (2023)Cite this article

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Disruptions in the autophagy–lysosome pathway in neurons have been implicated in Alzheimer’s disease. A study now reports that autophagy is also critical for disease-associated microglia surrounding amyloid plaques and is protective against microglial senescence and neuropathology in an Alzheimer’s disease mouse model.

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Fig. 1: Stalled autophagy switches microglia from DAM to senescence.

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Authors and Affiliations

  1. Helen and Robert Appel Alzheimer Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA

    Sadaf Amin, Bangyan Liu & Li Gan

  2. Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA

    Bangyan Liu & Li Gan

Authors
  1. Sadaf Amin
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  2. Bangyan Liu
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  3. Li Gan
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Correspondence to Li Gan.

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The authors declare no competing interests.

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Amin, S., Liu, B. & Gan, L. Autophagy prevents microglial senescence. Nat Cell Biol 25, 923–925 (2023). https://doi.org/10.1038/s41556-023-01168-y

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