Reprogramming of somatic cells is an inherently inefficient process. A new study has now identified histone H3K36 methylation as a crucial reprogramming barrier that operates downstream of TGFβ signalling. Global inhibition of H3K36 methylation induced PRC2-dependent silencing of mesenchymal genes and dramatically increased reprogramming efficiency.
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Cohen, L.R.Z., Meshorer, E. H3K36 methylation is a reprogramming barrier. Nat Cell Biol 25, 1077–1078 (2023). https://doi.org/10.1038/s41556-023-01147-3
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DOI: https://doi.org/10.1038/s41556-023-01147-3