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Intrinsically disordered CO2 sensors

Nature Cell Biology volume 24, pages 1013–1014 (2022)Cite this article

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Intrinsically disordered regions are a ubiquitous class of protein domains that lack a fixed 3D structure. Here, an evolutionarily conserved family of disordered CO2 sensors has been discovered, expanding the growing repertoire of disordered regions that respond to changes in the cellular environment.

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Fig. 1: An IDR-dependent CO2 sensor.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA

    Ryan J. Emenecker & Alex S. Holehouse

  2. Center for Science and Engineering Living Systems (CSELS), Washington University, St. Louis, MO, USA

    Ryan J. Emenecker & Alex S. Holehouse

Authors
  1. Ryan J. Emenecker
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  2. Alex S. Holehouse
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Correspondence to Alex S. Holehouse.

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Competing interests

A.S.H. is a scientific consultant with Dewpoint Therapeutics. R.J.E. has no competing interests.

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Emenecker, R.J., Holehouse, A.S. Intrinsically disordered CO2 sensors. Nat Cell Biol 24, 1013–1014 (2022). https://doi.org/10.1038/s41556-022-00957-1

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