Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by autoubiquitination and a soluble ERAD substrate.
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Betegon, M., Brodsky, J.L. Unlocking the door for ERAD. Nat Cell Biol 22, 263–265 (2020). https://doi.org/10.1038/s41556-020-0476-1
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DOI: https://doi.org/10.1038/s41556-020-0476-1