The TPLATE complex (TPC) is an ancient multi-subunit adaptor complex, essential for clathrin-mediated endocytosis in plants. We found that the evolutionary specific SH3 domain on the large TPC subunit, TASH3, recognizes ubiquitinated cargo proteins at the plasma membrane, providing a link between endocytosis and internalization of ubiquitinated proteins.
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References
Arora, D. & Van Damme, D. Motif-based endomembrane trafficking. Plant Physiol. 186, 221–238 (2021). A review article that gives an overview on protein trafficking, adaptor complexes and cargo recognition motifs.
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This is a summary of: Grones, P. et al. The endocytic TPLATE complex internalizes ubiquitinated plasma mebrane cargo. Nat. Plants https://doi.org/10.1038/s41477-022-01280-1 (2022).
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Ubiquitinated plasma membrane proteins are specifically recognized by the TPLATE complex. Nat. Plants 8, 1339–1340 (2022). https://doi.org/10.1038/s41477-022-01290-z
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DOI: https://doi.org/10.1038/s41477-022-01290-z