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References
Zhou X, Yang H, Song X, Wang J, Shen L, Wang J. Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension. Hypertens Res. 2019;42:1142–51.
Dupont AG, Brouwers S. Brain angiotensin peptides regulate sympathetic tone and blood pressure. J Hypertens. 2010;28:1599–610.
Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci. 2006;7:335–46.
Hu L, Zhu DN, Yu Z, Wang JQ, Sun ZJ, Yao T. Expression of angiotensin II type 1 (AT(1)) receptor in the rostral ventrolateral medulla in rats. J Appl Physiol (1985). 2002;92:2153–61.
Miyawaki T, Minson J, Arnolda L, Chalmers J, Llewellyn-Smith I, Pilowsky P. Role of excitatory amino acid receptors in cardiorespiratory coupling in ventrolateral medulla. Am J Physiol. 1996;271:1221–30.
Légat L, Smolders I, Dupont AG. AT1 receptor mediated hypertensive response to Ang II in the nucleus tractus solitarii of normotensive rats involves NO dependent local GABA release. Front Pharm. 2019;10:460.
Brouwers S, Smolders I, Wainford RD, Dupont AG. Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats. Clin Sci. 2015;129:81–92.
Légat L, Brouwers S, Smolders IJ, Dupont AG. Hypotensive response to angiotensin II Type 2 receptor stimulation in the rostral ventrolateral medulla requires functional GABA-A receptors. Front Neurosci 2017;11:346.
Gao L, Wang W, Li H, Sumners C, Zucker IH. Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats. Hypertension. 2008;51:521–7.
Menezes RC, Fontes MA. Cardiovascular effects produced by activation of GABA receptors in the rostral ventrolateral medulla of conscious rats. Neuroscience. 2007;144:336–43.
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Légat, L., Smolders, I. & Dupont, A.G. Angiotensin-II-mediated AT1 receptor stimulation increases glutamate release within the rostral ventrolateral medulla of normotensive rats. Hypertens Res 43, 848–850 (2020). https://doi.org/10.1038/s41440-020-0419-z
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DOI: https://doi.org/10.1038/s41440-020-0419-z