I have read with interest the recently published work “Prescription of exercise training for hypertensives” by Sakamoto [1]. The purpose of this study was to examine appropriate exercise prescriptions (e.g., type, intensity, duration per session, and frequency) for the prevention and treatment of hypertension.
The author elegantly discussed epidemiology, the pathophysiology of hypertension, factors considered to cause hypertension and the current status of exercise prescription for hypertension. Although the current study has interesting practical applications for endurance training, there are some methodological issues that might be of interest to readers, especially regarding the prescription of resistance training (RT) for hypertensive patients.
For example, there is no scientific evidence that RT should be performed at low intensity and should be used as supplementary exercise. The American Heart Association [2] recommends the practice of dynamic RT for the prevention and treatment of hypertension [90–150 min/week, 50–80% one repetition maximum (RM), six exercises, three sets per exercise and ten repetitions]. In addition, 60–70% 1RM represents moderate intensity, and 80% represents vigorous or high intensity. The prescription of RT should respect the biological principles of training, such as progressive overload, and hypertensive patients should not train until momentary concentric failure.
Several randomized controlled trials (control group and resistance training group) found that RT reduces systolic and diastolic blood pressure in prehypertensive [3] and hypertensive subjects [4,5,6,7] (Table 1). A meta-analysis by Sousa et al. [8] showed that RT alone reduces systolic and diastolic blood pressure in prehypertensive and hypertensive subjects. Furthermore, RT programs were found to be safe and well tolerated by hypertensive patients.
RT might have several benefits for patients with hypertension, such as decreasing peripheral vascular resistance [9], resting heart rate, resting double product [7], arterial stiffness, sympathetic tonus and neurohumoral alterations [3] (e.g., increased nitric oxide and reduced renin), which are factors that should influence postexercise hypotension. Furthermore, previous studies have reported that muscle strength has cardioprotective properties and that higher levels of muscle strength are associated with lower mortality rates in both the general population and hypertensive people [10].
References
Sakamoto S. Prescription of exercise training for hypertensives. Hypertens Res. 2020;43:155–61.
Whelton PK, Carey RM, Aronow WS Jr, Casey DE, Collins KJ, Himmelfarb D, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71:e13–115.
Tomeleri CM, Marcori AJ, Ribeiro AS, Gerage AM, Padilha CS, Schiavoni D, et al. Chronic blood pressure reductions and increments in plasma nitric oxide bioavailability. Int J Sports Med. 2017;38:290–9.
Oliveira-Dantas FF, Brasileiro-Santos Mdo S, Batista RM, do Nascimento LS, Castellano LR, Ritti-Dias RM, et al. Effect of strength training on oxidative stress and the correlation of the same with forearm vasodilatation and blood pressure of hypertensive elderly women: a randomized clinical trial. PLoS One. 2016;11:e0161178.
Mota MR, de Oliveira RJ, Dutra MT, Pardono E, Terra DF, Lima RM, et al. Acute and chronic effects of resistive exercise on blood pressure in hypertensive elderly women. J Strength Cond Res. 2013;27:3475–80.
Son WM, Pekas EJ, Park SY. Twelve weeks of resistance band exercise training improves age-associated hormonal decline, blood pressure, and body composition in postmenopausal women with stage 1 hypertension: a randomized clinical trial. Menopause. 2020;27:199–207.
Terra DF, Mota MR, Rabelo HT, Bezerra LM, Lima RM, Ribeiro AG, et al. Reduction of arterial pressure and double product at rest after resistance exercise training in elderly hypertensive women. Arq Bras Cardiol. 2008;91:299–305.
Sousa EC, Abrahin O, Ferreira ALL, Rodrigues RP, Alves EAC, Vieira RP. Resistance training alone reduces systolic and diastolic blood pressure in prehypertensive and hypertensive individuals: meta-analysis. Hypertens Res. 2017;40:927–31.
Oliveira-Dantas FF, Brasileiro-Santos MDS, Thomas SG, Silva AS, Silva DC, Browne RAV, et al. Short-term resistance training improves cardiac autonomic modulation and blood pressure in hypertensive older women: a randomized controlled trial. J Strength Cond Res. 2020;34:37–45.
Artero EG, Lee DC, Ruiz JR, Sui X, Ortega FB, Church TS, et al. A prospective study of muscular strength and all-cause mortality in men with hypertension. J Am Coll Cardiol. 2011;57:1831–7.
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Abrahin, O. Comment on “Prescription of exercise training for hypertensives”. Hypertens Res 44, 363–364 (2021). https://doi.org/10.1038/s41440-020-00598-7
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DOI: https://doi.org/10.1038/s41440-020-00598-7