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Computational identification of MiRNA-7110 from pulmonary arterial hypertension (PAH) ESTs: a new microRNA that links diabetes and PAH

Hypertension Research volume 43, pages 360–362 (2020)Cite this article

Pulmonary arterial hypertension (PAH) is a chronic cardiopulmonary disorder arising from the vasoconstriction of arteries wherein the blood flow is restricted, resulting in increased blood pressure [1]. PAH is characterized by increased vascular resistance, reduced apoptosis in endothelial cells and cardiac hypertrophy, which leads to right ventricular breakdown of the heart and finally leads to patient death [2]. Although numerous strategies have been improved for PAH control, including early diagnosis, surgery and the development of newer treatment methods, the treatment options for PAH are still suboptimal, resulting in a poor survival rate [2, 3]. MicroRNAs (miRNAs) are short, noncoding RNA molecules that regulate gene expression in cells by targeting the 3′ untranslated regions of their cognate mRNAs [4, 5]. Interestingly, miRNAs are involved in cell proliferation, differentiation, apoptosis and other cellular developmental processes [6]. There are several studies linking the aberrant expression and deregulation of miRNAs with vascular pathophysiological conditions that include immune and inflammatory responses, aging, cancer and cardiovascular diseases. Fortunately, miRNAs are more stable than mRNAs in cells and are readily detected in plasma, platelets, red blood cells and other nucleated cells [6], suggesting that miRNAs may be used as biomarkers and therapeutic molecules for PAH [7].

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Acknowledgements

This work was supported by a grant from the Indian Council of Medical Research (ICMR) (No: 2019-0106/CMB/ADHOC/BMS).

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  1. Dental Research Cell (DRC-BRULAC), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, 600077, India

    Jayapriya Johnson & Durairaj Sekar

  2. Department of Anatomy, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, 600077, India

    Ganesh Lakshmanan

  3. Department of Animal Health and Management, Alagappa University, Tamil Nadu, 630003, India

    Biruntha M

  4. Department of Bioinformatics, Alagappa University, Tamil Nadu, 630003, India

    Vidhyavathi R.M

  5. Department of Obstetrics and Gynaecology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, 600077, India

    Kohila Kalimuthu

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  1. Jayapriya Johnson
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Correspondence to Durairaj Sekar.

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Johnson, J., Lakshmanan, G., M, B. et al. Computational identification of MiRNA-7110 from pulmonary arterial hypertension (PAH) ESTs: a new microRNA that links diabetes and PAH. Hypertens Res 43, 360–362 (2020). https://doi.org/10.1038/s41440-019-0369-5

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