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N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases

Hypertension Research volume 43, pages 153–154 (2020)Cite this article

To the Editor:

Mo et al. showed that m6A plays important roles in blood pressure regulation in a report in Hypertension Research [4]. m6A mRNA methylation regulates cardiac gene expression and cellular growth [5]. Mathiyalagan et al. recently identified m6A as a novel mechanism of human CD34+ stem cell-derived exosomes in cardiac repair [6]. Furthermore, this RNA modification regulates cardiomyocyte Ca2+ dynamics and cardiac function [7].

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References

  1. Stellos K. The rise of epitranscriptomic era: implications for cardiovascular disease. Cardiovasc Res. 2017;113:e2–e3.

    Article  CAS  Google Scholar 

  2. Pagiatakis C, Condorelli G. The RNA methylome blackboard: METTL3 and FTO, epigenetic writers and erasers regulating cardiac homeostasis through epitranscriptome modification. Circulation. 2019;139:546–8.

    Article  Google Scholar 

  3. Su H, Zhou L, Li N, Wang G, Wu L, Ma X, et al. Transcriptome-wide map of m6A circRNAs identified in hypoxic pulmonary hypertension rat model. 2019. https://doi.org/10.1101/625178.

  4. Mo XB, Lei SF, Zhang YH, Zhang H. Examination of the associations between m A-associated singlenucleotide polymorphisms and blood pressure. Hypertens Res. 2019. https://doi.org/10.1038/s41440-019-0277-8.

    Article  CAS  Google Scholar 

  5. Kmietczyk V, Riechert E, Kalinski L, Boileau E, Malovrh E, Malone B, et al. m6A-mRNA methylation regulates cardiac gene expression and cellular growth. Life Sci Alliance. 2019;2:e201800233.

    Article  Google Scholar 

  6. Mathiyalagan P, Liang Y, Adamiak M, Sassi Y, Agarwal N, Ishikawa K, et al. Modulation of N6-Methyladenosine (m6A) as a novel mechanism of human CD34+ stem cell-derived exosomes in cardiac repair. Circulation. 2017;136:A18434.

    Google Scholar 

  7. Mathiyalagan P, Liang Y, Sassi Y, Kohlbrenner E, Chen J, Lebeche D, et al. M6A Modification in RNA regulates cardiomyocyte and cardiac function in heart failure. Circ Res. 2017;121:A12.

    Google Scholar 

  8. Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M, et al. The N6-Methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy. Circulation. 2019;139:533–45.

    Article  CAS  Google Scholar 

  9. Marcadenti A, Fuchs FD, Matte U, Sperb F, Moreira LB, Fuchs SC. Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension. Cardiovasc Diabetol. 2013;12:103.

    Article  Google Scholar 

  10. Olza J, Ruperez AI, Gil-Campos M, Leis R, Fernandez-Orth D, Tojo R, et al. Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case–control multicentre study. BMC Med Genet. 2013;14:123.

    Article  Google Scholar 

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  1. BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India

    Arumugam Paramasivam & Jayaseelan Vijayashree Priyadharsini

  2. Centre for Biotechnology, Anna University, Chennai, India

    Subramanian Raghunandhakumar

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  1. Arumugam Paramasivam
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Paramasivam, A., Vijayashree Priyadharsini, J. & Raghunandhakumar, S. N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases. Hypertens Res 43, 153–154 (2020). https://doi.org/10.1038/s41440-019-0338-z

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