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Hyperfluorescence of choroidal arteries in the peripheral fundus on late-phase ICGA

Eye volume 37, pages 3502–3505 (2023)Cite this article

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Abstract

Aims

To correlate the hyperfluorescent lines in the peripheral fundus on late-phase indocyanine green angiography (ICGA) to infrared and optical coherence tomography (OCT) findings.

Methods

This is a retrospective, cross-sectional study. Multimodal imaging data, including ICGA, fluorescein angiography, infrared imaging, and OCT were analyzed. The hyperfluorescent lines were categorized into 2 grades according to their extents. In addition, serum levels of apolipoprotein (Apo) A and B were measured by enzyme linked immunosorbent assay.

Results

A total of 247 patients who underwent multimodal imaging were reviewed. The hyperfluorescent lines in the peripheral fundus on late-phase ICGA were detected in 96 patients, and were correlated to superficial choroidal arteries by infrared imaging and OCT. The incidence of hyperfluorescent choroidal arteries in the peripheral fundus (HCAP) on late-phase ICGA increased in groups of older ages (0–20 years, 4.3%; 20–40 years, 2.6%; 40–60 years, 48.9%; >60 years, 88.7%; p < 0.001). In addition, the mean age increased with the grades of HCAP (grade 1, 52.3 ± 10.8 years; grade 2, 63.3 ± 10.5 years; p < 0.001). The hyperfluorescence was also detected in posterior choroidal arteries in 11 eyes, all patients in grade 2. There was no significant correlation between grades of HCAP and gender, or serum level of ApoA and ApoB.

Conclusion

The occurrence and grades of HCAP increased with age. The superficial location of choroidal arteries in the peripheral fundus exposes their hyperfluorescence on late-phase ICGA. HCAP might reveal the local lipid degeneration of choroidal artery walls, according to ICG binding properties.

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Fig. 1: Grading the hyperfluorescence of choroidal arteries in the peripheral fundus (HCAP) according to their extents.
Fig. 2: Hyperfluorescence of choroidal arteries in the peripheral fundus (HCAP) on late-phase ICGA correlated to RPE humps on OCT.
Fig. 3: Hyperfluorescent choroidal arteries in the posterior pole on late-phase ICGA (yellow arrowhead) in a 79-year-old man.

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Data availability

The data generated and analyzed during this study are available upon reasonable request from the corresponding author.

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Funding

This work was supported by the National Natural Science Foundation of China (81870674, 82070970).

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Author notes

  1. These authors contributed equally: Miaoling Li, Xiongze Zhang.

Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China

    Miaoling Li, Xiongze Zhang, Yuying Ji, Lan Mi & Feng Wen

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  1. Miaoling Li
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  2. Xiongze Zhang
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Contributions

MLL and XZZ contributed to study design. MLL was responsible for collecting data, interpreting data, and writing the report. YYJ and LM contributed to data collection and reviewing the report. FW supervised the study, analyzed data and reviewed the report.

Corresponding author

Correspondence to Feng Wen.

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Li, M., Zhang, X., Ji, Y. et al. Hyperfluorescence of choroidal arteries in the peripheral fundus on late-phase ICGA. Eye 37, 3502–3505 (2023). https://doi.org/10.1038/s41433-023-02545-5

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