Abstract
Background
We aim to characterise the ophthalmic findings and retinal vasculature changes in patients with WS, and to analyse the correlation between ophthalmic manifestations and the associated systemic diseases.
Methods
This retrospective case-control study included 27 WS patients and 28 age-matched healthy participants. Stellate pattern of iris, central macular thickness (CMT), foveal width, retinal vessel diameter, superficial vascular density (SVD) of macula and foveal avascular zone (FAZ) were compared between WS patients and healthy participants.
Results
Twenty-five patients (93%) had the classic stellate iris presentation. Compared with healthy controls, WS patients had decreased CMT, increased foveal width and a lower SVD of macula (all P < 0.001). Significantly decreased mean retinal arterial (117.9 ± 9.9 µm vs. 133.0 ± 6.7 µm in WS and controls, respectively; p < 0.001) and venous (158.9 ± 11.2 µm vs. 174.0 ± 8.0 µm in WS and controls, respectively; p < 0.001) outer diameters, as well as mean arterial wall thickness (11.2 ± 1.3 µm vs. 12.2 ± 0.8 µm in WS and controls, respectively; p < 0.01) were found in WS. Stellate iris grading was significantly associated with CMT, foveal width, retinal vessel diameter (all p < 0.05), and a significant increase in the odds of having hypertension (Odds ratio (OR), 5.63; P < 0.05). The severity of stellate iris in WS seemed to have the trend of increasing risk of having pulmonary stenosis, tricuspid regurgitation and mitral regurgitation.
Conclusions
This study provides the first in vivo evidence reflecting current knowledge on vessel morphology in WS patients that deficient circumferential growth is the predominant pathophysiologic changes resulting from elastin deficiency. The ophthalmic characteristics may serve as a complementary tool to diagnose and follow-up patients suffering from WS.
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Data availability
The data that support the findings of this study are available upon reasonable request.
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Funding
This study is supported by Taipei Veterans General Hospital (grant no. VGH V110C-052, V111C-099) and Ministry of Science and Technology of Taiwan (grant no. MOST 110-2314-B-075-054-MY3, MOST 111-2324-B-075-42).
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(I) Conception and design: T-CY, H-CC, D-MN, A-GW (II) Administrative support: H-YL, SCC, H-YY, J-YY. (III) Provision of study materials or patients: H-CC, A-GW. (IV) Collection and assembly of data: T-CY. (V) Data analysis and interpretation: T-CY, H-CC, A-GW. (VI) Paper writing: T-CY, H-CC. (VII) Final approval of paper: All authors.
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Yeh, TC., Cheng, HC., Li, HY. et al. Ophthalmic characteristics and retinal vasculature changes in Williams syndrome, and its association with systemic diseases. Eye 37, 2265–2271 (2023). https://doi.org/10.1038/s41433-022-02328-4
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DOI: https://doi.org/10.1038/s41433-022-02328-4