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Nutrigenomics and molecular nutrition

The interaction of cholesteryl ester transfer protein gene variations and diet on changes in serum lipid profiles

European Journal of Clinical Nutrition volume 73, pages 1291–1298 (2019)Cite this article

Subjects

Abstract

Background/Objectives

Gene–diet interactions may have an important role in the disparities between the lipid responses of individuals to diet. This study aimed to investigate whether polymorphisms (rs5882 and rs3764261) in the cholesteryl ester transfer protein (CETP) gene modify the association of diet with changes in serum lipid profiles.

Subjects/Methods

A total of 4700 individuals aged ≥18 years were selected from among participants of the Tehran Lipid and Glucose Study. After 3.6 years of follow-up, changes in serum lipid profiles were evaluated. Usual dietary intake was assessed using a validated food frequency questionnaire. DNA samples were genotyped with HumanOmniExpress-24-v1-0 bead chips (containing 649,932 SNP loci).

Results

No significant interaction was found between CETP polymorphisms and dietary patterns in changing lipid profiles. Mean changes of total cholesterol (TC) decreased in higher quartiles of fish intake in A allele carriers (Q1:8.02, Q4:5.58, Ptrend = 0.01) compared to the CC genotype (Q1:3.65, Q4:8.93, Ptrend = 0.11) (Pi = 0.02). There are ascending trends of changes in triglyceride (TG) concentrations across quartiles of total fat, monounsaturated and saturated fat consumption in G allele carriers of rs5882 compared to the AA genotype. There was a declining trend for mean changes in TG concentrations across quartiles of carbohydrate intake in G allele carriers of rs5882 compared to the AA genotype (Pi = 0.01).

Conclusions

Our data demonstrated that minor allele carriers of rs5882 had a better TG value than AA homozygote individuals when consuming a low fat and high carbohydrate diet. Fish intake modifies the association of rs3764261with TC concentrations.

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Acknowledgements

The authors wish to acknowledge Ms. Niloofar Shiva and Dr. Forough Ghanbari for critical editing of the English grammar and syntax of the manuscript.

Author contributions

ZE, FHE and AG designed the study, analysed and interpreted the data, while also drafting the manuscript; MSD, PM and FA supervised the study, revised the manuscript for important intellectual content and final approval of the version for publication.

Funding

This study was supported by the RIES, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant No. 834).

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Authors and Affiliations

  1. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Firoozeh Hosseini-Esfahani & Zohre Esfandiar

  2. Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Parvin Mirmiran

  3. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maryam S. Daneshpour

  4. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Arash Ghanbarian

  5. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Fereidoun Azizi

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Correspondence to Parvin Mirmiran or Maryam S. Daneshpour.

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Hosseini-Esfahani, F., Esfandiar, Z., Mirmiran, P. et al. The interaction of cholesteryl ester transfer protein gene variations and diet on changes in serum lipid profiles. Eur J Clin Nutr 73, 1291–1298 (2019). https://doi.org/10.1038/s41430-019-0397-x

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