Brief Communication | Published:

Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women

European Journal of Clinical Nutrition (2018) | Download Citation


Data were derived from the National Institute for Longevity Sciences-Longitudinal Study of Aging. Subjects comprised 403 men and 373 women aged 60–81 years at baseline who participated in the follow-up study at least once. Bean, soy product and soy isoflavone intake was assessed using a 3-day dietary record at baseline. Cognitive function was assessed by the Mini-Mental State Examination (MMSE). MMSE scores of ≤23 were used to define cognitive impairment. The relationship between bean, soy product and soy isoflavone intake and cognitive impairment was assessed using a generalized estimating equation. Multivariate-adjusted odds ratios (95% confidence intervals) for cognitive impairment with a 1 s.d. increase in total bean, total soybean and total soy isoflavone intakes were 0.48 (0.28–0.81; p = 0.006), 0.51 (0.32–0.83; p = 0.007), and 0.55 (0.32–0.93; p = 0.026), respectively, in women. Total soybean and soy isoflavone intake might decrease the risk of cognitive impairment in elderly Japanese women.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from $8.99

All prices are NET prices.


  1. 1.

    International WHO’s. Dementia: A Public Health Priority 2012. 2012.

  2. 2.

    Ren MQ, Kuhn G, Wegner J, Chen J. Isoflavones, substances with multi-biological and clinical properties. Eur J Nutr. 2001;40:135–46.

  3. 3.

    McEwen BS. Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol. 2001;91:2785–801.

  4. 4.

    Hogervorst E, Mursjid F, Priandini D, Setyawan H, Ismael RI, Bandelow S, et al. Borobudur revisited: soy consumption may be associated with better recall in younger, but not in older, rural Indonesian elderly. Brain Res. 2011;1379:206–12.

  5. 5.

    White LR, Petrovitch H, Ross GW, Masaki K, Hardman J, Nelson J, et al. Brain aging and midlife tofu consumption. J Am Coll Nutr. 2000;19:242–55.

  6. 6.

    Huang MH, Luetters C, Buckwalter GJ, Seeman TE, Gold EB, Sternfeld B, et al. Dietary genistein intake and cognitive performance in a multiethnic cohort of midlife women. Menopause. 2006;13:621–30.

  7. 7.

    Shimokata H, Ando F, Niino N. A new comprehensive study on aging--the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol. 2000;10(1 Suppl):S1–9.

  8. 8.

    Imai T, Sakai S, Mori K, Ando F, Niino N, Shimokata H. Nutritional assessments of 3-day dietary records in National Institute for Longevity Sciences--Longitudinal Study of Aging (NILS-LSA). J Epidemiol. 2000;10(1 Suppl):S70–6.

  9. 9.

    Khosla S, Melton LJ 3rd, Atkinson EJ, O’Fallon WM. Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab. 2001;86:3555–61.

  10. 10.

    Floyd RA, Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging. 2002;23:795–807.

Download references


We obtained written informed consent for study participation from each participant. The study protocol was reviewed and approved by the Committees of Ethics of Human Research of the National Center for Geriatrics and Gerontology. The authors thank the study participants and our colleagues in the NILS-LSA for completing the survey for this study.

Author contributions

All the authors (MN, RO, YN, CT, MT, YK, TI, TS, FA and HS) developed the idea for this study. RO, YN, CT, MT, YK, TI, FA, and HS collected the data. Measurements and data analysis was completed by MN. FA and HS provided medical advice regarding interpretation of the data. MN drafted the manuscript with the help of RO. All authors read and approved the final version of the manuscript.

Author information


  1. Department of Public Health and Applied Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    • Mariko Nakamoto
    •  & Tohru Sakai
  2. Section of NILS-LSA, National Center for Geriatrics and Gerontology, Aichi, Japan

    • Mariko Nakamoto
    • , Rei Otsuka
    • , Yukiko Nishita
    • , Chikako Tange
    • , Makiko Tomida
    • , Yuki Kato
    • , Tomoko Imai
    • , Fujiko Ando
    •  & Hiroshi Shimokata
  3. Faculty of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan

    • Yuki Kato
    •  & Fujiko Ando
  4. Faculty of Human Life and Science, Doshisha Women’s College of Liberal Arts, Kyoto, Japan

    • Tomoko Imai
  5. Graduate School of Nutritional Sciences, Nagoya University of Arts and Sciences, Aichi, Japan

    • Hiroshi Shimokata


  1. Search for Mariko Nakamoto in:

  2. Search for Rei Otsuka in:

  3. Search for Yukiko Nishita in:

  4. Search for Chikako Tange in:

  5. Search for Makiko Tomida in:

  6. Search for Yuki Kato in:

  7. Search for Tomoko Imai in:

  8. Search for Tohru Sakai in:

  9. Search for Fujiko Ando in:

  10. Search for Hiroshi Shimokata in:

Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Mariko Nakamoto.

About this article

Publication history