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Verbalide A~F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972

The Journal of Antibiotics volume 76, pages 613–617 (2023)Cite this article

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Abstract

There are six new phthalide derivatives Verbalide A ~ F (1–6) together with another known derivative (7) isolated from the endophytic fungus Preussia sp. CPCC 400972. Their structures were established by comprehensive spectroscopic analyses, including NMR and HRESIMS. In addition, compounds 1–7 exhibited excellent inhibitory effect against influenza A virus.

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Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81973220), CAMS Innovation Fund for Medical Sciences (No. 2021-I2M-1-055), the National Microbial Resource Center (No. NMRC-2022-3).

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Authors and Affiliations

  1. China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Ran Zhang, Guowei Cai, Juxian Wang, Jinglin Bai, Tao Zhang, Wenni He & Liyan Yu

  2. Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Yujia Wang, Jianyuan Zhao & Shan Cen

  3. Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China

    Yujia Wang, Jianyuan Zhao, Jinglin Bai, Tao Zhang, Shan Cen & Liyan Yu

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  1. Ran Zhang
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Correspondence to Wenni He or Liyan Yu.

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Zhang, R., Wang, Y., Cai, G. et al. Verbalide A~F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972. J Antibiot 76, 613–617 (2023). https://doi.org/10.1038/s41429-023-00640-z

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