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Two new 22-membered macrolides from Streptomyces sp. HU210

The Journal of Antibiotics volume 75, pages 650–653 (2022)Cite this article

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Abstract

Two new 22-membered macrolide metabolites, phthoramycins B (1) and C (2), were isolated from the fermentation broth of Streptomyces sp. HU210. Their structures were elucidated based on extensive spectroscopic techniques including 1D, 2D NMR and HRESIMS data. Compounds 1 and 2 showed moderate cytotoxic activity against human leukemia cell line K562 and lung carcinoma cell line A549.

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References

  1. Atanasov AG, Zotchev SB, Dirsch VM, the international Natural Product Sciences Taskforce, Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Disco. 2021;20:200–16.

    Article  CAS  Google Scholar 

  2. Singh H, Kaur M, Jangra M, Mishra S, Nandanwar H, Pinnaka AK. Antimicrobial properties of the novel bacterial isolate Paenibacilllus sp. SMB1 from a halo-alkaline lake in India. Sci Rep. 2019;9:11561.

    Article  Google Scholar 

  3. Takagi M, Shin-ya K. Construction of a natural product library containing secondary metabolites produced by actinomycetes. J Antibiot. 2012;65:443–7.

    Article  CAS  Google Scholar 

  4. Fenical W, Jensen PR. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat Chem Biol. 2006;2:666–73.

    Article  CAS  Google Scholar 

  5. Shirai M, Okuda M, Motohashi K, Imoto M, Furihata K, Matsuo Y. et al. Terpenoids produced by actinomycetes: isolation, structural elucidation and biosynthesis of new diterpenes, gifhornenolones A and B from Verrucosispora gifhornensis YM28-088. J Antibiot. 2010;63:245–50.

    Article  CAS  Google Scholar 

  6. Hu GP, Yuan J, Sun L, She ZG, Wu JH, Lan XJ. et al. Statistical research on marine natural products based on data obtained between 1985 and 2008. Mar Drugs. 2011;9:514–25.

    Article  Google Scholar 

  7. Bhatnagar I, Kim SK. Pharmacologically prospective antibiotic agents and their sources: a marine microbial perspective. Environ Toxicol Phar. 2012;34:631–43.

    Article  CAS  Google Scholar 

  8. Sayed AM, Hassan MHA, Alhadrami HA, Hassan HM, Goodfellow M, Rateb ME. Extreme environments: microbiology leading to specialised metabolites. J Appl Microbiol. 2019;128:630–57.

    Article  Google Scholar 

  9. Huang HY, Xu XG, Liu XS, Han RM, Liu JE, Wang GX. Distributions of four taste and odor compounds in the sediment and overlying water at different ecology environment in Taihu Lake. Sci Rep. 2018;8:6179.

    Article  Google Scholar 

  10. Wu X, Xi WY, Ye WJ, Yang H. Bacterial community composition of a shallow hypertrophic freshwater lake in China, revealed by 16S rRNA gene sequences. Fems Microbiol Ecol. 2007;61:85–96.

    Article  CAS  Google Scholar 

  11. Hochlowski JE, Mullally MM, Brill GM, Whittern DN, Buko AM, Hill P. et al. Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity II. Isolation and elucidation of structures. J Antibiot. 1991;44:1318–30.

    Article  CAS  Google Scholar 

  12. Fredenhagen A, Derrien C, Gassmann E. An MS/MS library on an ion-trap instrument for efficient dereplication of natural products. Different fragmentation patterns for [M + H]+ and [M + Na]+ ions. J Nat Prod. 2005;68:385–91.

    Article  CAS  Google Scholar 

  13. Nakagawa A, Miura S, Imai H, Imamura N, Ōmura S. Structure and biosynthesis of a new antifungal antibiotic, phthoramycin. J Antibiot. 1989;42:1324–7.

    Article  CAS  Google Scholar 

  14. Ye YH, Anwar N, Mao XM, Wu SH, Yan C, Zhao Z. et al. Discovery of three 22-membered macrolides by deciphering the streamlined genome of mangrove-derived Streptomyces sp. HM190. Front Microbiol. 2020;11:1464

    Article  Google Scholar 

  15. Wang JD, Zhang H, Yang XH, Zhou Y, Wang HB, Bai H. HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071. J Antibiot. 2008;61:623–6.

    Article  CAS  Google Scholar 

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Acknowledgements

The research was financially supported by the Key Research and Development Program of Zhejiang Province (Grant No: 2020C02028) and the National Key Research and Development Program of China (2021YFC2600104).

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  1. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, 313000, China

    Cheng-Hong Zhang, Huan Qi, Bing Li, Shao-Yong Zhang, Li-Qin Zhang & Ji-Dong Wang

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  1. Cheng-Hong Zhang
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Correspondence to Ji-Dong Wang.

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Zhang, CH., Qi, H., Li, B. et al. Two new 22-membered macrolides from Streptomyces sp. HU210. J Antibiot 75, 650–653 (2022). https://doi.org/10.1038/s41429-022-00563-1

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