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Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi

The Journal of Antibiotics volume 75, pages 514–518 (2022)Cite this article

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Abstract

In our screening program for new antifungal active compounds, a new modified γ-lactone curvicollide D (1) together with five known trichothecenes (2–6) were isolated from the culture filtrate of fungus Albifimbria verrucaria based on the in vitro antifungal assay. The chemical structure of new compound 1 was elucidated by NMR and HR-MS spectroscopic analyses, and the relative configurations of 1 were deduced from NOE experiments and coupling constant analysis. Compound 1 exhibited moderate antifungal activities against plant pathogenic fungi Botrytis cinerea, Colletotrichum coccodes, and Magnaporthe oryzae with MIC value in a range of 100–200 µg ml–1. Moreover, trichothecene compounds (2–6) displayed a broad spectrum of antifungal activities with MIC values in a range of 6.3–100 µg ml–1.

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Acknowledgements

This study was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through Crop Viruses and Pests Response Industry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (No. 321101-03). We thank the Korea Basic Science Institute for recording HR-ESI-MS and FT-IR data.

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  1. Center for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, 34114, Korea

    Minh Van Nguyen, Jae Woo Han, Hun Kim & Gyung Ja Choi

  2. Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Korea

    Minh Van Nguyen, Hun Kim & Gyung Ja Choi

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  1. Minh Van Nguyen
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Correspondence to Hun Kim or Gyung Ja Choi.

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Nguyen, M.V., Han, J.W., Kim, H. et al. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi. J Antibiot 75, 514–518 (2022). https://doi.org/10.1038/s41429-022-00541-7

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