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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study

The Journal of Antibiotics volume 73, pages 798–802 (2020)Cite this article

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Abstract

Six known indole alkaloid derivatives have been isolated for the first time from Bacillus thuringiensis and Bacillus velezensis strains, all of them as building blocks for the synthesis of larger natural products. Their structure was elucidated by a complete spectroscopy. Their biological activities were tested against some Gram-positive and Gram-negative bacteria and three phytopathogenic fungi which cause diseases in important crops, such as Moniliophthora roreri, the causal agent of cacao disease. The results indicated that some compounds had modest antibacterial activity; however, some of them had strong antifungal activity against the probed fungi. This antifungal activity of these compounds has not been reported.

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Acknowledgements

We thank VIEP and CONACyT (251512).

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  1. Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 72570, Puebla, PUE, Mexico

    Jessica Vaca, Francisco Salazar, Aurelio Ortiz & Estibaliz Sansinenea

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  1. Jessica Vaca
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  2. Francisco Salazar
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  3. Aurelio Ortiz
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  4. Estibaliz Sansinenea
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Correspondence to Estibaliz Sansinenea.

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Indole Alkaloid Derivatives as Building Blocks of Natural Products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study

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Vaca, J., Salazar, F., Ortiz, A. et al. Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study. J Antibiot 73, 798–802 (2020). https://doi.org/10.1038/s41429-020-0333-2

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