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Fluorophore-glucan conjugate for oligosaccharide sensing in aqueous media

Polymer Journal volume 56, pages 473–480 (2024)Cite this article

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Abstract

The ability to sense saccharides in aqueous media using conventional supramolecular approaches was a turning point in modern chemistry. Herein, we performed oligosaccharide sensing using fluorophore-modified branched glucans. Through the newly developed glucan-based chemosensor, acarbose sensing was achieved in a selectively and sensitive manner. The optical properties and morphological changes in the chemosensor were investigated, revealing that the globule-to-coaggregation process plays a key role in oligosaccharide sensing.

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Acknowledgements

GF acknowledges the generous support provided by Grants-in-Aid (Nos. 19H02746 and 23H04020) from the Japan Society for the Promotion of Science (JSPS). We are grateful to Prof. Yoshihisa Inoue at Osaka University for fruitful discussions.

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Authors and Affiliations

  1. Department of Applied Chemistry, Osaka University, 2-1 Yamada-oka, Suita, 565-0871, Japan

    Hiroki Kurohara

  2. Department of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8551, Japan

    Yumiko Hori & Gaku Fukuhara

  3. Department of Biomolecular Chemistry, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo, Sakyo-ku, Kyoto, 606-8522, Japan

    Munenori Numata

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  1. Hiroki Kurohara
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Correspondence to Gaku Fukuhara.

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Kurohara, H., Hori, Y., Numata, M. et al. Fluorophore-glucan conjugate for oligosaccharide sensing in aqueous media. Polym J 56, 473–480 (2024). https://doi.org/10.1038/s41428-024-00889-7

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  • DOI: https://doi.org/10.1038/s41428-024-00889-7

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