Supramolecular chemistry

Definition

Supramolecular chemistry is the study of entities of greater complexity than individual molecules — assemblies of molecules that bond and organize through intermolecular interactions. The design and synthesis of supramolecular systems invokes interactions beyond the covalent bond, using, for example, hydrogen bonding, metal coordination and π interactions to bring discrete building blocks together.

Featured

Latest Research and Reviews

  • Research | | open

    The complex, multicomponent structures often found in nature are difficult to mimic synthetically. Here, the authors assemble a molecular analogue of a peanut through coordinative and π-stacking interactions, in which a polyaromatic double capsule ‘pod’ held together by metal ions encapsulates fullerene ‘beans’.

    • Kohei Yazaki
    • , Munetaka Akita
    • , Soumyakanta Prusty
    • , Dillip Kumar Chand
    • , Takashi Kikuchi
    • , Hiroyasu Sato
    •  & Michito Yoshizawa
  • Research |

    An attractive feature of supramolecular polymers is their reversibility — they typically depolymerize upon heating. Now, in the presence of a scavenger molecule, a metalloporphyrin derivative bearing eight amide-containing side chains has been shown to undergo supramolecular polymerization on heating as well as cooling through π-stacking and multivalent hydrogen-bonding interactions.

    • Kotagiri Venkata Rao
    • , Daigo Miyajima
    • , Atsuko Nihonyanagi
    •  & Takuzo Aida
  • Research | | open

    The self-assembly of block copolymers to form micelles has been used in applications such as drug delivery and composite reinforcement. Here the authors explore the use of fibre-like micelles of controlled length in the active layer of field-effect transistor devices.

    • Xiaoyu Li
    • , Piotr J. Wolanin
    • , Liam R. MacFarlane
    • , Robert L. Harniman
    • , Jieshu Qian
    • , Oliver E. C. Gould
    • , Thomas G. Dane
    • , John Rudin
    • , Martin J. Cryan
    • , Thomas Schmaltz
    • , Holger Frauenrath
    • , Mitchell A. Winnik
    • , Charl F. J. Faul
    •  & Ian Manners
  • Research | | open

    Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.

    • M. T. Jeena
    • , L. Palanikumar
    • , Eun Min Go
    • , Inhye Kim
    • , Myoung Gyun Kang
    • , Seonik Lee
    • , Sooham Park
    • , Huyeon Choi
    • , Chaekyu Kim
    • , Seon-Mi Jin
    • , Sung Chul Bae
    • , Hyun Woo Rhee
    • , Eunji Lee
    • , Sang Kyu Kwak
    •  & Ja-Hyoung Ryu

News and Comment