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Development of peptide–inorganic hybrid materials based on biomineralization and their functional design based on structural controls

Polymer Journal volume 55, pages 817–827 (2023)Cite this article

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Abstract

The functional design of hard tissues by structural control during biomineralization has attracted attention as a novel method for the development of next-generation functional materials that are based on living organisms. In previous studies, the mechanisms of formation and crystal growth of inorganic matter during mineralization have been investigated. However, these mechanisms have yet to lead to the establishment of a principle that can collectively explain the phenomenon occurring during this process. In this review, the advantages associated with the molecular design of peptides as multifunctional templates for mineralization are initially described. Subsequently, the mechanisms of CaCO3 nucleation and selective crystal growth achieved under biomimetic mineralization conditions using the designed peptide templates are discussed. Finally, the functional design of peptide–inorganic hybrid materials based on structural control and the use of a mineralization method that can be applied in the engineering and medical fields are considered from the viewpoint of the molecular properties of the peptides. Overall, the described studies provided significant breakthroughs for the improvement of the functionalities of organic–inorganic hybrid materials based on the use of biomineralization-inspired environmentally friendly processes.

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Acknowledgements

This research was supported by Grant-in-Aid for JSPS Fellow (14J06876), Grant-in-Aid for Young Scientists (Grant Nos. 16K18250 and 20K15340) from the Japan Society for the Promotion of Science and the Foundation for the Promotion of Ion Engineering. I would like to thank Editage (www.wditage.com) for English language editing.

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  1. Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano, 386-8567, Japan

    Kazuki Murai

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  1. Kazuki Murai
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Correspondence to Kazuki Murai.

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Murai, K. Development of peptide–inorganic hybrid materials based on biomineralization and their functional design based on structural controls. Polym J 55, 817–827 (2023). https://doi.org/10.1038/s41428-023-00783-8

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