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Injectable inclusion complex composed of α-cyclodextrin and hydrophobically modified poly(vinyl alcohol) as a cerebral aneurysm embolization material

Polymer Journal volume 52, pages 793–802 (2020)Cite this article

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Abstract

Surgical therapy (clipping) and endovascular therapy (coiling) are the main treatment options for people with cerebral aneurysms. In recent years, minimally invasive coil embolization has been recommended. However, the surgical method presents challenges in terms of the filling rate and operability, thus highlighting the need for a novel embolization material. In this study, injectable inclusion complexes for cerebral aneurysm treatment were prepared by α-cyclodextrin (α-CD) and hydrophobically modified poly(vinyl alcohol) (hm-PVA) with various alkyl chain lengths (3, 9, and 18). 2D-NMR NOESY spectra indicated that a threaded inclusion complex was formed between α-CD and hm-PVA. By mixing hm-PVAs with different concentrations of α-CD, only hm-PVA (5 mol% nonanal-modified PVA (5C9-PVA)) with 15 mM α-CD showed good thixotropic properties. In addition, this inclusion complex showed gel–sol transition behavior under different strain amplitudes (1 and 1000%). The α-CD/5C9-PVA inclusion complex showed good injectability, even when using a 25 G needle. After injecting the α-CD/5C9-PVA inclusion complex into an in vitro cerebral aneurysm model, it formed aggregates in phosphate buffer solution at 37 °C and filled the whole area. These results demonstrate that the α-CD/5C9-PVA inclusion complex could be an ideal material for cerebral aneurysm treatment.

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Acknowledgements

We acknowledge Dr A. Nishiguchi, Mrs M. Katano, Mrs S. Watanabe, and Mrs Y. Kurihara from the Polymeric Biomaterials Group at the National Institute for Materials Science (NIMS) for their technical support. This research was partially supported by the Project for Japan Translational and Clinical Research Core Centers from the Japan Agency for Medical Research and Development (AMED), “Innovation Inspired by Nature” Research Support Program, SEKISUI CHEMICAL CO. LTD, and the Uehara Memorial Foundation.

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  1. Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan

    Xi Chen & Tetsushi Taguchi

  2. Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan

    Xi Chen & Tetsushi Taguchi

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Correspondence to Tetsushi Taguchi.

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Chen, X., Taguchi, T. Injectable inclusion complex composed of α-cyclodextrin and hydrophobically modified poly(vinyl alcohol) as a cerebral aneurysm embolization material. Polym J 52, 793–802 (2020). https://doi.org/10.1038/s41428-020-0321-1

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