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References
Li Y, Wang X. The role of cullin4B in human cancers. Exp Hematol Oncol. 2017;6:17.
Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, et al. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012;22:781–95.
Hung MH, Jian YR, Tsao CC, Lin SW, Chuang YH. Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages. Genes Immun. 2014;15:404–12.
Qian Y, Yuan J, Hu H, Yang Q, Li J, Zhang S, et al. The CUL4B/AKT/beta-catenin axis restricts the accumulation of myeloid-derived suppressor cells to prohibit the establishment of a tumor-permissive microenvironment. Cancer Res. 2015;75:5070–83.
Xu Z, Li L, Qian Y, Song Y, Qin L, Duan Y, et al. Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells. Oncogene. 2019;38:5860–72.
Song Y, Li P, Qin L, Xu Z, Jiang B, Ma C, et al. CUL4B negatively regulates toll-like receptor-triggered proinflammatory responses by repressing Pten transcription. Cell Mol Immunol. 2021;18:339–49.
Dar AA, Sawada K, Dybas JM, Moser EK, Lewis EL, Park E, et al. The E3 ubiquitin ligase Cul4b promotes CD4+ T-cell expansion by aiding the repair of damaged DNA. PLoS Biol. 2021;19:e3001041.
Qin L, Song Y, Zhang F, Wang R, Zhou L, Jin S, et al. CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation. Cell Death Differ. 2023; https://doi.org/10.1038/s41418-023-01155-8.
Jin S, Song Y, Zhou L, Jiang W, Qin L, Wang Y, et al. Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell Rep. 2023;42:112550.
Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, et al. Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet. 2007;80:561–6.
Tarpey PS, Raymond FL, O’Meara S, Edkins S, Teague J, Butler A, et al. Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet. 2007;80:345–52.
Zong Y, Shan H, Yin F, Ma X, Jiang C, Wang N, et al. Ddb1-Cullin4-associated-Factor 1 in macrophages restricts the staphylococcus aureus-induced osteomyelitis. J Inflamm Res. 2021;14:1667–76.
Yang L, Chen W, Li L, Xiao Y, Fan S, Zhang Q, et al. Ddb1 is essential for the expansion of CD4(+) helper T cells by regulating cell cycle progression and cell death. Front Immunol. 2021;12:722273.
Tumes DJ, Onodera A, Suzuki A, Shinoda K, Endo Y, Iwamura C, et al. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells. Immunity. 2013;39:819–32.
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This work is supported by the National Natural Science Foundation of China (82171851) to YG.
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YS drafted the manuscript. SJ drew the figure. GS and YG revised the manuscript.
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Song, Y., Jin, S., Sun, G. et al. Cullin 4B-RING E3 ligase complex in immune cell differentiation and function. Cell Mol Immunol 20, 1254–1256 (2023). https://doi.org/10.1038/s41423-023-01045-6
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DOI: https://doi.org/10.1038/s41423-023-01045-6