Retraction to: Cell Death and Disease https://doi.org/10.1038/s41419-020-02793-3, published online 24 July 2020
The Editors-in-Chief have retracted this article. After publication, concerns were raised regarding suspected image duplication and overlap. Specifically:
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In Fig. 3a, the cell growth curves for the two cell lines appear highly similar;
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In Fig. 3e, the H&E images for shRNA#1 and shRNA#2 appear to overlap;
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In Fig. 3h, the intestine images in the scramble and shRNA#1 groups appear to originate from the same sample;
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Also in Fig. 3h, the liver images in the shRNA#1 and shRNA#2 groups appear highly similar (rotated 90 degrees with brightness adjustment);
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In Fig. 4c HCT116 shRNA data, the bands representing OSBPL3 and P27 appear highly similar (rotated 180 degrees);
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In Fig. 5a, the HCT15 OSBPL3 bands appear highly similar to the HCT166 OSBPL3 and P27 blots in Fig. 4c;
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In Fig. S2g, the image representing the HCT15 vector group appears highly similar to Fig. S6e RKO HIF1a+OSBPL3-shRNA#1;
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In Fig. S3f, the images for HCT116 shRNA#1 and shRNA#2 appear to overlap.
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In Table 1, the total patient numbers in the low and high OSBPL3 expression groups are inconsistent.
The Editors-in-Chief therefore no longer have confidence in the presented data.
None of the authors have responded to any correspondence from the editor or publisher about this retraction.
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Jiao, Hl., Weng, Bs., Yan, Ss. et al. Retraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway. Cell Death Dis 13, 920 (2022). https://doi.org/10.1038/s41419-022-05367-7
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DOI: https://doi.org/10.1038/s41419-022-05367-7