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RETRACTED ARTICLE: Upregulating microRNA-498 inhibits gastric cancer proliferation invasion and chemoresistance through inverse interaction of Bmi1

Cancer Gene Therapy volume 26, pages 366–373 (2019)Cite this article

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A Retraction to this article was published on 01 July 2021

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Abstract

This study aimed to analyze the functions of microRNA 498 (miR-498) on gastric cancer (GC) cell proliferation migration and cisplatin chemosensitivity. QTR-PCR found that miR-498 was markedly downregulated in GC cell lines and human GC tumors. It was discover that, lentivirus-mediated miR-498 overexpression inhibited cancer cell proliferations in vitro and in vivo, invasion and cisplatin chemoresistance. Bmi1 was demonstrated to be directly regulated by miR-498 in GC cell lines. Moreover, Bmi1 upregulation was found to reverse the tumor-suppressing functions of miR-498 in GC. Therefore, this study presented evidence showing miR-498 expression decreased in GC, and overexpressing miR-498 had significant inhibitory effects on GC development, likely through the inverse interaction of Bmi1.

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Author notes

  1. These authors contribute equally: Tiancheng Zhao, Yahong Chen

Authors and Affiliations

  1. Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, 130000, China

    Tiancheng Zhao

  2. Department of Gastrointestinal surgery, China-Japan Union Hospital of Jilin University, Changchun, 130000, China

    Yahong Chen, Shihou Sheng, Yuanyu Wu & Tao Zhang

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  1. Tiancheng Zhao
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  2. Yahong Chen
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  3. Shihou Sheng
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Correspondence to Shihou Sheng.

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Zhao, T., Chen, Y., Sheng, S. et al. RETRACTED ARTICLE: Upregulating microRNA-498 inhibits gastric cancer proliferation invasion and chemoresistance through inverse interaction of Bmi1. Cancer Gene Ther 26, 366–373 (2019). https://doi.org/10.1038/s41417-018-0065-7

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