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Complementary therapies for fatigue after hematopoietic stem cell transplantation: an integrative review

Bone Marrow Transplantation volume 53, pages 556–564 (2018)Cite this article

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Abstract

Fatigue after hematopoietic stem cell transplantation (HSCT) is a persistent problem that limits activities and causes distress. Complementary therapies have shown promising results in improving fatigue in several patient populations. However, it is unknown whether they have the same effect on fatigue in the HSCT population. This integrative review aimed to explore the literature that evaluated complementary therapies for fatigue among HSCT patients. Only eight studies were considered eligible for inclusion in this review. The eight studies evaluated music therapy, relaxation, mindfulness, and massage techniques with mixed results. These studies had major methodological limitations, such as the small sample sizes and not blinding participants to the treatment allocation, introducing possible bias. Furthermore, most of these studies used ‘usual care’ control groups, leaving it unclear to what extent the observed effects are based on the effects of complementary therapies, or rather on psychosocial factors such as personal attention. More research is needed to more rigorously evaluate these and other complementary therapies for the prevalent problem of fatigue in the HSCT population.

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References

  1. Wingard JR, Majhail NS, Brazauskas R, Wang Z, Sobocinski KA, Jacobsohn D, et al. Long-term survival and late deaths after allogeneic hematopoietic cell transplantation. J Clin Oncol. 2011;29(16):2230–9. https://doi.org/10.1200/JCO.2010.33.7212.

    Article  PubMed  PubMed Central  Google Scholar 

  2. National Comprehensive Cancer Network. Definition of cancer-related fatigue. https://www.nccn.org/professionals/physician_gls/pdf/fatigue.pdf. Accessed 9 June 2017.

  3. Bower JE, Cancer-related fatigue: links with inflammation in cancer patients and survivors. Brain Behav Immun. 2007;21(7):863–71. S0889-1591(07)00077-3 [pii].

    Article  CAS  Google Scholar 

  4. Bower JE, Lamkin D. Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications. Brain Behav Immun. 2013;30:S48–57.

    Article  CAS  Google Scholar 

  5. Bevans MF, Mitchell SA, Marden S. The symptom experience in the first 100 days following allogeneic hematopoietic stem cell transplantation (HSCT). Support Care Cancer. 2008;16(11):1243–54.

    Article  Google Scholar 

  6. Mosher CE, Duhamel KN, Rini C, Corner G, Lam J, Redd WH. Quality of life concerns and depression among hematopoietic stem cell transplant survivors. Support Care Cancer. 2011;19(9):1357–65.

    Article  Google Scholar 

  7. Gielissen MF, Schattenberg AV, Verhagen CA, Rinkes MJ, Bremmers ME, Bleijenberg G. Experience of severe fatigue in long-term survivors of stem cell transplantation. Bone Marrow Transplant. 2007;39(10):595–603. doi:1705624 [pii]

    Article  CAS  Google Scholar 

  8. Im A, Mitchell SA, Steinberg SM, Curtis L, Berger A, Baird K, et al. Prevalence and determinants of fatigue in patients with moderate to severe chronic GvHD. Bone Marrow Transplant. 2016;51(5):705–12. https://doi.org/10.1038/bmt.2015.320.

    Article  CAS  PubMed  Google Scholar 

  9. National Comprehensive Cancer Network. Cancer-related fatigue guidelines. Version I. 2016. https://www.nccn.org/professionals/physician_gls/pdf/fatigue.pdf. Accessed 9 June 2017.

  10. Oncology Nursing Society. Fatigue guidelines. Updated 21 January 2016. https://www.ons.org/practice-resources/pep/fatigue. Accessed 9 June 2017.

  11. Barton DL, Pachman DR. Clinical trials in integrative therapies. Semin Oncol Nurs. 2012;28(1):10–28. https://doi.org/10.1016/j.soncn.2011.11.003.

    Article  PubMed  Google Scholar 

  12. Sood A, Barton DL, Bauer BA, Loprinzi CL. A critical review of complementary therapies for cancer-related fatigue. Integr Cancer Ther. 2007;6(1):8–13.

    Article  Google Scholar 

  13. Finnegan-John J, Molassiotis A, Richardson A, Ream E. A systematic review of complementary and alternative medicine interventions for the management of cancer-related fatigue. Integr Cancer Ther. 2013;12(4):276–90. https://doi.org/10.1177/1534735413485816.

    Article  PubMed  Google Scholar 

  14. National Center for Complementary and Integrative Health. Complementary, alternative, or integrative health: what’s in a name? Updated March 2015. https://nccih.nih.gov/health/integrative-health. Accessed 9 June 2017.

  15. Bower JE, Greendale G, Crosswell AD, Garet D, Sternlieb B, Ganz PA, et al. Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial. Psychoneuroendocrinology. 2014;43:20–9. https://doi.org/10.1016/j.psyneuen.2014.01.019.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Oh B, Butow P, Mullan B, Clarke S, Beale P, Pavlakis N, et al. Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial. Ann Oncol. 2009;21(3):608–14.

    Article  Google Scholar 

  17. Cassileth BR, Vickers AJ, Magill LA, Music therapy for mood disturbance during hospitalization for autologous stem cell transplantation: a randomized controlled trial. Cancer. 2003;98(12):2723–9. https://doi.org/10.1002/cncr.11842.

    Article  PubMed  Google Scholar 

  18. Rosenow SC, Silverman MJ. Effects of single session music therapy on hospitalized patients recovering from a bone marrow transplant: two studies. Arts Psychother. 2014;41(1):65–70. https://doi.org/10.1016/j.aip.2013.11.003.

    Article  Google Scholar 

  19. Fredenburg HA, Silverman MJ. Effects of cognitive-behavioral music therapy on fatigue in patients in a blood and marrow transplantation unit: a mixed-method pilot study. Arts Psychother. 2014;41(5):433–44. https://doi.org/10.1016/j.aip.2014.09.002.

    Article  Google Scholar 

  20. Kim S, Kim H. Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs. 2005;14(1):51–5. https://doi.org/10.1111/j.1365-2702.2004.00938.x

    Article  PubMed  Google Scholar 

  21. Lu DF, Hart LK, Lutgendorf SK, Oh H, Silverman M. Effects of healing touch and relaxation therapy on adult patients undergoing hematopoietic stem cell transplant: a feasibility pilot study. Cancer Nurs. 2015;39(3):E1–E11p. https://doi.org/10.1097/NCC.0000000000000272.

    Article  Google Scholar 

  22. Grossman P, Zwahlen D, Halter JP, Passweg JR, Steiner C, Kiss A. A mindfulness-based program for improving quality of life among hematopoietic stem cell transplantation survivors: feasibility and preliminary findings. Support Care Cancer. 2015;23(4):1105–12. https://doi.org/10.1007/s00520-014-2452-4.

    Article  PubMed  Google Scholar 

  23. Ahles TA, Tope DM, Pinkson B, Walch S, Hann D, Whedon M, et al. Massage therapy for patients undergoing autologous bone marrow transplantation. J Pain Symptom Manage. 1999;18(3):157–63.

    Article  CAS  Google Scholar 

  24. Zhang L, Wang S, Chen H, Yuan A. Tai chi exercise for cancer-related fatigue in patients with lung cancer undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manage. 2016;51(3):504–11. https://doi.org/10.1016/j.jpainsymman.2015.11.020.

    Article  PubMed  Google Scholar 

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Acknowledgements

 The authors would like to thank Dr. Cynthia Arslanian-Engoren, Dr. Mark Peterson, Dr. Sung Choi, Dr. Moira Visovatti, Dr. Lauren Wallner, and Dr. Barbara L. Brush for generously offering their time, support, and guidance throughout the course of this review.  

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  1. School of Nursing, University of Michigan, Ann Arbor, MI, USA

    Mohamad Baydoun & Debra L. Barton

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  1. Mohamad Baydoun
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Correspondence to Mohamad Baydoun.

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Baydoun, M., Barton, D.L. Complementary therapies for fatigue after hematopoietic stem cell transplantation: an integrative review. Bone Marrow Transplant 53, 556–564 (2018). https://doi.org/10.1038/s41409-017-0073-5

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