Correction to: Oncogene https://www.nature.com/articles/onc2016165, published online 16 May 2016

Following the publication of the above article, the authors noted an error in Fig. 4e (left, T24-ShC). We found that this image was duplicated and misused from T24-ShC cells in Fig. 3a (left, T24-ShC). We do not believe that this mistake would have any consequence on the scientific conclusions reached in the article. We apologize for any inconvenience caused by this careless error.

Fig. 4: MTSS1 is responsible for MAEL-induced UCB cell invasiveness and EMT.
figure 4

a The seven genes, EWSR1, MTSS1, MDM2, MMP2, Flt4, CCL7, and FGFR4, were examined more than twofold mRNA differential expression in T24-MAEL-shRNA-1 cells compared to that in T24-shControl cells by using a Human Tumor Metastasis RT² Profiler™ PCR Array. b Silence of MAEL by shRNA-1 in T24 cells substantially upregulated MTSS1 expression and downregulated Flt4 expression as examined by Western blotting. c Overexpression of MAEL and low-level expression of MTSS1 was examined by IHC in a UCB case; scale bar, 100 μm. d Western blot shows that MTSS1 was efficiently knocked down by the treatment of siMTSS1 in T24-MAEL-shRNA-1 cells. e Wound-healing and Transwell assays show that knockdown of MTSS1 substantially increased the migration (upper) and invasion (down) abilities of T24-MAEL-shRNA-1 cells. Data are the means ± SD of three independent experiments; scale bar, 100 μm. *P < 0.05, **P < 0.01 by the Student’s t test. f Western blotting shows that after silence of MTSS1 by specific siRNA in T24-MAEL-shRNA-1 cells, the levels of E-cadherin and β-catenin decreased, while the levels of fibronectin and vimentin increased (left). IF staining demonstrates a downregulated expression of E-cadherin and an upregulated expression of vimentin in T24-MAEL-shRNA-1 cells, after knock down of MTSS1 (right).

Full size image

This correction notice contains the original image from T24-ShC cells, and was completely corrected in Fig. 4e.