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NTproBNP as a surrogate biomarker for early screening of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia

Journal of Perinatology volume 38, pages 1252–1257 (2018)Cite this article

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Abstract

Objective

Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants.

Study design

Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups. Statistical analyses included repeated measures analysis of variance and receiver operator curve (ROC) generation.

Results

Infants in the BPD-PH and BPD group had significantly elevated NTproBNP levels as compared to the control group. ROC curves for NTproBNP at 28 weeks CGA provided a cut-point of 2329 pg/ml and 578.1 pg/ml for detection of BPD-PH and BPD, respectively.

Conclusions

NTproBNP appears to be a good screening tool to determine the onset of BPD-PH as early as 28 weeks CGA.

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Funding

No financial support was received in the preparation of this manuscript

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Children’s Healthcare of Atlanta, Atlanta, GA, USA

    Soham Dasgupta

  2. Department of Pediatric Cardiology, University of Texas Medical Branch, Galveston, TX, USA

    Ashraf M. Aly

  3. Department of Neonatology, University of Texas Medical Branch, Galveston, TX, USA

    Michael H. Malloy & Sunil K. Jain

  4. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

    Anthony O. Okorodudu

Authors
  1. Soham Dasgupta
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  2. Ashraf M. Aly
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  5. Sunil K. Jain
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Corresponding author

Correspondence to Sunil K. Jain.

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The authors declare that they have no conflict of interest.

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Dasgupta, S., Aly, A.M., Malloy, M.H. et al. NTproBNP as a surrogate biomarker for early screening of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. J Perinatol 38, 1252–1257 (2018). https://doi.org/10.1038/s41372-018-0164-1

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