Neonatal streptozotocin treatment of mice born to control mothers revealed replaced pancreatic beta cell mass by day 30 that was not sustained. In contrast offspring exposed antenatally to a low protein environment demonstrated a limited capacity for recovery of the pancreatic beta cell mass.
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Gastroschisis-like abdominal wall defect observed in aortic carboxypeptidase-like protein null mice is associated with defect in neuromuscular development that is restricted to the eviscerated intestine.
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Angiotensin II regulates neuronal and endothelial nitric oxide synthase (NOS) expression and NOS activity in afferent arterioles of the developing porcine kidney via AT1 and AT2 receptors.
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Regenerated bone marrow on the scaffold is capable of supporting and delivering hematopoietic stem cells (HSCs) to native murine bone marrow in-vivo, thereby serving as a portable source of HSCs.
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FasL signaling has dual timing-dependent effects of pro-apoptosis in antenatal and pro-proliferative in postnatal periods on post-canalicular type II cell kinetics.
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Hyperoxia-induced airway hyper-reactivity in neonatal rats is mediated partly via mast cells. Both cromolyn and imatinib blocked mast cell accumulation in airways.
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Editor's Focus. Pediatr Res 68, i (2010). https://doi.org/10.1203/PDR.0b013e3181e88936
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DOI: https://doi.org/10.1203/PDR.0b013e3181e88936