Abstract 1697

The cholesterol content of human mild (15 md/dL) is five-fold greater than that of the standard infant formulas based on bovine milk (3 mg/dL). It has been proposed to supplement preterm formulas (PF) with cholesterol. Previous unpublished data showed that plasma 25-hydroxyvitramin D (25OHD) decreased in infants fed cholesterol supplemented PF. Hypothesis : plasma 25OHD decreases with increasing dietary intake. Methods : 30 preterm infants were assigned to receive randomly and blindly one of the 3 study PF with different cholesterol content (PF1<mg/dL, PF2 : 15 mg/dL, PF3 : 30mg/dL) until they reached theoretical term (TT). Daily oral Vitamin D supplementation (1000IU) was similar in the 3 groups. Plasma 25OHD, 1-25OHD, calcium, phosphorus and alkaline phosphatases (AP) were measured at time of inclusion (I) and three months later (TT). Kruskall-Wallis test was used for comparison of the 3 groups. Results in 20 infants are shown in table (mean±SD) : Conclusion : Preliminary results showed no effect of dietary cholesterol intake on vitamin D metabolites and AP plasma concentrations in preterm infants fed PF supplemented with 15 or 30 mg/dL.

Table 1 No caption available
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