Many factors exert influence in obtaining a good metabolic control in patients with Type I diabetes (DMI). Objective-a) To evaluate the influence of the presence of ICA at diagnosis in C-peptide secretion during the first year of follow-up. b) To study the realtionship between IA and insulin dose and type. We analysed 14 patients, diagnosed within 6 weeks, with chronological age=9.8y (2.3-22y). 9F and 5 M, in a double-blind, prospective study. ICA were detected by imunoperoxidase technique (A-protein/peroxidase in rat pancreas), limit of sensibility = 101DFU.1A dosage- RIA (NV <60nU/mL). We analysed HbA1 levels (affinity cromatography- nv=3.6-5.3%), and C-peptide(RIE-kit DPC) basal and after stimulation with Sustacal, before NCT introduction and each three months during the first year. Insulin dose was also assessed (units per kilo - U/Kg). Patients with ICA negative (n=5); ICA positive (n=9). Values of C-peptide (CP) in relation to ICA:Table

Table 1
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There was no correlation between presence of ICA and CP secretion. In relation to IA, patients were divided accordingly to the type of insulin - Pork and beet or pork. Patients using pork insulin (n=6) had IA values=2937-1705n U/mL(median=2909), significantly lower (p=0.044) than those with pork-beet insulin (n=8)-4100-2031 nU/mL(median=4059). Insulin dose used by patients with pork insulin was 0.61+0.28, and tended to be lower (p=0.066) than in the pork-beet group - 0.75+0.24. There was no correlation between IA and CP, basal or peak, and between IA and HbA1. We concluded that the presence of ICA at diagnosis had no influence in CP values during the first year of follow-up. In relation to IA, there was a relation with the specimen of insulin used, which could be influencing insulin dose, and that they seem not to be related to insulin secretion